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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PMP70 Polyclonal Antibody
catalog :
PA1-650
quantity :
100 ug
price :
US 562.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 6a
Ranea Robles P, Portman K, Bender A, Lee K, He J, Mulholland D, et al. Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice. Kidney360. 2021;2:1441-1454 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 5d
Malvi P, Janostiak R, Nagarajan A, Zhang X, Wajapeyee N. N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production. Mol Metab. 2021;48:101217 pubmed publisher
  • western blot; human; loading ...; fig 1h
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, et al. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 2019;: pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
  • immunocytochemistry; human; 1:1000; loading ...; fig 4i
Sychev Z, Hu A, Dimaio T, Gitter A, Camp N, Noble W, et al. Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism. PLoS Pathog. 2017;13:e1006256 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig s3a
Lee M, Sumpter R, Zou Z, Sirasanagandla S, Wei Y, Mishra P, et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 2017;18:48-60 pubmed publisher
Zhang N, Wang Y, Sun C, Shi Y, Hou L, Yao M, et al. High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway. Am J Cancer Res. 2023;13:1884-1903 pubmed
Mu xf1 oz Estrada J, Nguyen A, Goetz S. TTBK2 mutations associated with spinocerebellar ataxia type 11 disrupt peroxisome dynamics and ciliary localization of SHH signaling proteins. bioRxiv. 2023;: pubmed publisher
Borgia P, Baldassari S, Pedemonte N, Alkhunaizi E, D Onofrio G, Tortora D, et al. Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders. Orphanet J Rare Dis. 2022;17:286 pubmed publisher
Braccia C, Christopher J, Crook O, Breckels L, Queiroz R, Liessi N, et al. CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium. Cells. 2022;11: pubmed publisher
Zappa F, Muniozguren N, Wilson M, Costello M, Ponce Rojas J, Acosta Alvear D. Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering. J Cell Biol. 2022;221: pubmed publisher
Terabayashi T, Menezes L, Zhou F, Cai H, Walter P, GARRAFFO H, et al. Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism. Kidney360. 2021;2:1576-1591 pubmed publisher
Ranea Robles P, Chen H, Stauffer B, Yu C, Bhattacharya D, Friedman S, et al. The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis. J Inherit Metab Dis. 2021;44:1419-1433 pubmed publisher
Ravi A, Palamiuc L, Loughran R, Triscott J, Arora G, Kumar A, et al. PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Dev Cell. 2021;56:1661-1676.e10 pubmed publisher
Mori H, Dugan C, Nishii A, Benchamana A, Li Z, Cadenhead T, et al. The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures. PLoS Biol. 2021;19:e3000988 pubmed publisher
Klouwer F, Falkenberg K, Ofman R, Koster J, van Gent D, Ferdinandusse S, et al. Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect. Front Cell Dev Biol. 2021;9:661298 pubmed publisher
Bugarski M, Ghazi S, Polesel M, Martins J, Hall A. Changes in NAD and Lipid Metabolism Drive Acidosis-Induced Acute Kidney Injury. J Am Soc Nephrol. 2021;32:342-356 pubmed publisher
Preidis G, Soni K, Suh J, Halder T, Kim K, Choi J, et al. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun. 2020;4:1835-1850 pubmed publisher
Alexander C, Martin J, Oxman E, Kasza I, Senn K, Dvinge H. Alternative Splicing and Cleavage of GLUT8. Mol Cell Biol. 2020;41: pubmed publisher
Evans A, Daly J, Anuar A, Simonetti B, Cullen P. Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting. J Cell Sci. 2020;133: pubmed publisher
Mao C, Lee M, Jhan J, Halpern A, Woodworth M, Glaser A, et al. Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy. Sci Adv. 2020;6:eaba4542 pubmed publisher
Song K, Zhang Y, Brenner B, Sun C, Zhang H. Symmetrically dispersed spectroscopic single-molecule localization microscopy. Light Sci Appl. 2020;9:92 pubmed publisher
Kumar Gaire S, Zhang Y, Li H, Yu R, Zhang H, Ying L. Accelerating multicolor spectroscopic single-molecule localization microscopy using deep learning. Biomed Opt Express. 2020;11:2705-2721 pubmed publisher
Torres S, Gallagher C, Plate L, Gupta M, Liem C, Guo X, et al. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. elife. 2019;8: pubmed publisher
Ageta H, Ageta Ishihara N, Hitachi K, Karayel Ö, Onouchi T, Yamaguchi H, et al. UBL3 modification influences protein sorting to small extracellular vesicles. Nat Commun. 2018;9:3936 pubmed publisher
Young P, Senkal C, Suchanek A, Grevengoed T, Lin D, Zhao L, et al. Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways. J Biol Chem. 2018;293:16724-16740 pubmed publisher
Ledvina H, Kelly K, Eshraghi A, Plemel R, Peterson S, Lee B, et al. A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella. Cell Host Microbe. 2018;24:285-295.e8 pubmed publisher
Lin J, Mironova Y, Shrager P, Giger R. LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair. elife. 2017;6: pubmed publisher
Debbabi M, Nury T, Helali I, Karym E, Geillon F, Gondcaille C, et al. Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells. Methods Mol Biol. 2017;1595:257-265 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PMP70 Polyclonal Antibody
Catalog # :
PA1-650
Quantity :
100 ug
Price :
US 562.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 0.5 ug/test, Immunocytochemistry: 1-10 ug/mL, Western Blot: 1:500
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum' disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
Immunogen :
Synthetic Peptide: C N(644) Y E F K K I T E D T V E F G S(659)
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test, Immunocytochemistry: 1-10 ug/mL, Western Blot: 1:500
Aliases :
68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; 70-kDa peroxisomal membrane protein; ABC43; ABCD3; AI313901; ATP binding cassette subfamily D member 3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, subfamily D (ALD), member 3; ATP-binding cassette, sub-family D (ALD), member 3; AU018866; AW146054; CBAS5; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); Peroxisomal membrane protein 1; peroxisomal membrane protein 1 (70kD, Zellweger syndrome); peroxisomal membrane protein, 70 kDa; Peroxisomal membrane protein-1 (70kD); PMP68; Pmp70; Pxmp1; ZWS2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA