Endostatin Polyclonal Antibody | Invitrogen PA1-601 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Endostatin Polyclonal Antibody

catalog :

PA1-601

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 4

Reference
Bonet A, Valen xe7 a A, Mendes Jorge L, Casellas A, Rodr xed guez Baeza A, Nacher V, et al. Decreased endostatin in db/db retinas is associated with optic disc intravitreal vascularization. Exp Eye Res. 2021;212:108801 pubmed publisher
Ojalill M, Virtanen N, Rappu P, Siljamäki E, Taimen P, Heino J. Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins. Prostate. 2020;80:715-726 pubmed publisher
Huaman J, Naidoo M, Zang X, Ogunwobi O. Fibronectin Regulation of Integrin B1 and SLUG in Circulating Tumor Cells. Cells. 2019;8: pubmed publisher
Martín Granado V, Ortiz Rivero S, Carmona R, Gutiérrez Herrero S, Barrera M, San Segundo L, et al. C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis. Oncotarget. 2017;8:110994-111011 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Endostatin Polyclonal Antibody

Catalog # :

PA1-601

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.

Immunogen :

Synthetic peptides corresponding to residues R(1718) R L M E S Y C E T W R T E(1731) of Mouse Endostatin and R(1699) R L T E S Y C E T W R T E(1712) of Human Endostatin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 2 ug/mL

Aliases :

antiangiogenic agent; Col18a1; Collagen alpha-1(XVIII) chain; collagen type XVIII alpha 1 chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; KNO; KNO1; KS; MGC74745; multi-functional protein MFP; NC1; Non-collagenous domain 1; procollagen, type XVIII, alpha 1