CaMKIV Polyclonal Antibody | Invitrogen PA1-542 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CaMKIV Polyclonal Antibody

catalog :

PA1-542

quantity :

100 ug

price :

US 491.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, Xenopus laevis

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Zech M, Lam D, Weber S, Berutti R, Poláková K, Havrankova P, et al. A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder. Cold Spring Harb Mol Case Stud. 2018;: pubmed publisher
Maeda K, Otomo K, Yoshida N, Abu Asab M, Ichinose K, Nishino T, et al. CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease. J Clin Invest. 2018;128:3445-3459 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CaMKIV Polyclonal Antibody

Catalog # :

PA1-542

Quantity :

100 ug

Price :

US 491.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Non-human primate, Plant, Rat, Xenopus laevis

Applications :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 1 ug/mL

Species :

Canine, Human, Mouse, Non-human primate, Plant, Rat, Xenopus laevis

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Immunogen :

Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 1 ug/mL

Aliases :

A430110E23Rik; AI666733; brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; Ca2+/calmodulin-dependent protein kinase type IV/Gr; Calcium/calmoduli; calcium/calmodulin dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV L homeolog; calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calmodulin-dependent protein kinase IV; calspermin; CAM kinase- GR; CAM kinase IV; CAM kinase-GR; CAMK; CaMK IV; camk4; camk4.L; camk4-A; CAMK-GR; CAMKIV; CaMKIV/Gr; Ccdpk; D18Bwg0362e; EC 2.7.11.17; KCC4; kinase CaMK4; OTTHUMP00000222818; RATCCDPK; xCaM; XELAEV_18008011mg