PER1 Polyclonal Antibody | Invitrogen PA1-524 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PER1 Polyclonal Antibody

catalog :

PA1-524

quantity :

200 uL

price :

US 419.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 3

Reference
Sundaram S, Nagaraj S, Mahoney H, Portugués A, Li W, Millsaps K, et al. Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease. Sci Rep. 2019;9:13743 pubmed publisher
Kwapis J, Alaghband Y, Kramar E, Lopez A, Vogel Ciernia A, White A, et al. Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nat Commun. 2018;9:3323 pubmed publisher
Hirano A, Braas D, Fu Y, PtÃ¡Äek L. FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice. Cell Rep. 2017;19:255-266 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PER1 Polyclonal Antibody

Catalog # :

PA1-524

Quantity :

200 uL

Price :

US 419.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Frozen): 1:50-1:500, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:100-1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

Immunogen :

Synthetic Peptide: P(39) S L A D D T D A N S N G(51) C

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:200, Immunohistochemistry (Frozen): 1:50-1:500, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:100-1:1,000

Aliases :

circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; hPER; hPER1; KIAA0482; mPer1; m-rigui; PER; PER1; per1 {ECO:0000312; period 1; period circadian clock 1; period circadian protein homolog 1; period homolog 1; Period, drosophila, homolog of; RGD:727863}; RIGUI; rPER1