Glucocorticoid Receptor alpha Polyclonal Antibody | Invitrogen PA1-516 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glucocorticoid Receptor alpha Polyclonal Antibody

catalog :

PA1-516

quantity :

50 µg

price :

US 430.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2	Bergström I, Lundberg A, Jonsson S, Särndahl E, Ernerudh J, Jonasson L. Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity. PLoS ONE. 2017;12:e0174177 pubmed publisher
western blot; human; 1 ug/ml; fig 2	Vitellius G, Fagart J, Delemer B, Amazit L, Ramos N, Bouligand J, et al. Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance. Hum Mutat. 2016;37:794-803 pubmed publisher
immunocytochemistry; human; fig 4	Grundy S, Plumb J, Kaur M, Ray D, Singh D. Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells. Respir Res. 2016;17:9 pubmed publisher
	Shao S, Wang Y, Zhao Y, Xu Y, Wang T, Du K, et al. Identification of multiple isoforms of glucocorticoid receptor in nasal polyps of patients with chronic rhinosinusitis. J Otolaryngol Head Neck Surg. 2022;51:25 pubmed publisher
	Zhang C, Wang J, Wenkel S, Chandler J, Werr W, Jiao Y. Spatiotemporal control of axillary meristem formation by interacting transcriptional regulators. Development. 2018;145: pubmed publisher
	Le Billan F, Amazit L, Bleakley K, Xue Q, Pussard E, Lhadj C, et al. Corticosteroid receptors adopt distinct cyclical transcriptional signatures. FASEB J. 2018;32:5626-5639 pubmed publisher
	Scofield S, Murison A, Jones A, Fozard J, Aida M, Band L, et al. Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development. 2018;145: pubmed publisher
	Nicolaides N, Kino T, Roberts M, Katsantoni E, Sertedaki A, Moutsatsou P, et al. The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (hGR) in Mediating the Nongenomic Glucocorticoid Actions. J Mol Biochem. 2017;6:3-12 pubmed
	Reyes Olalde J, Zúñiga Mayo V, Serwatowska J, Chávez Montes R, Lozano Sotomayor P, Herrera Ubaldo H, et al. The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium. PLoS Genet. 2017;13:e1006726 pubmed publisher
	Shi B, Zhang C, Tian C, Wang J, Wang Q, Xu T, et al. Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis. PLoS Genet. 2016;12:e1006168 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Glucocorticoid Receptor alpha Polyclonal Antibody

Catalog # :

PA1-516

Quantity :

50 µg

Price :

US 430.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: 4 µg/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity

Immunogen :

Synthetic Peptide: C(755) E I I T N Q I P K Y S N G N I K K(771)

Format :

Lyophilized

Applications w/Dilutions :

ChIP Assay: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: Assay-dependent, Western Blot: 4 µg/mL

Aliases :

cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038

more info or order :

Invitrogen product webpage