Glucocorticoid Receptor Polyclonal Antibody | Invitrogen PA1-512 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glucocorticoid Receptor Polyclonal Antibody

catalog :

PA1-512

quantity :

50 ug

price :

US 500.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

citations: 3

Reference
Alavi M, Ryabinin A, Helms M, Nipper M, Devaud L, Finn D. Sensitivity and Resilience to Predator Stress-Enhanced Ethanol Drinking Is Associated With Sex-Dependent Differences in Stress-Regulating Systems. Front Behav Neurosci. 2022;16:834880 pubmed publisher
Perry R, RINCON CORTES M, Braren S, Brandes Aitken A, Opendak M, Pollonini G, et al. Corticosterone administration targeting a hypo-reactive HPA axis rescues a socially-avoidant phenotype in scarcity-adversity reared rats. Dev Cogn Neurosci. 2019;40:100716 pubmed publisher
Kiuchi Z, Nishibori Y, Kutsuna S, Kotani M, Hada I, Kimura T, et al. GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells. FASEB J. 2019;33:7387-7402 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Glucocorticoid Receptor Polyclonal Antibody

Catalog # :

PA1-512

Quantity :

50 ug

Price :

US 500.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: Assay-dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:20-1:100, Immunohistochemistry (Frozen): 1 ug/mL, Immunoprecipitation: 5 ug/mL, Western Blot: 1-5 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity

Immunogen :

Synthetic peptide corresponding to residues C(245) K P L I L P D T K P K I K D(259) of human GR.

Format :

Lyophilized

Applications w/Dilutions :

ChIP Assay: Assay-dependent, Gel Shift: Assay-dependent, Immunocytochemistry: 1:20-1:100, Immunohistochemistry (Frozen): 1 ug/mL, Immunoprecipitation: 5 ug/mL, Western Blot: 1-5 ug/mL

Aliases :

cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038