Tyrosine Hydroxylase Polyclonal Antibody | Invitrogen PA1-4679 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosine Hydroxylase Polyclonal Antibody

catalog :

PA1-4679

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5d western blot; mouse; 1:1000; loading ...; fig 5c	Song L, McMackin M, Nguyen A, Cortopassi G. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiol Dis. 2017;100:30-38 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:2000; fig 2	Bouilloux F, Thireau J, VentÃ©o S, Farah C, Karam S, Dauvilliers Y, et al. Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. elife. 2016;5: pubmed publisher
	Alshaman R, Qushawy M, Mokhtar H, Ameen A, El Sayed R, Alamri E, et al. Marula oil nanoemulsion improves motor function in experimental parkinsonism via mitigation of inflammation and oxidative stress. Front Pharmacol. 2023;14:1293306 pubmed publisher
	Neuman S, Metzger J, Bondarenko V, Wang Y, Felton J, Levine J, et al. Striatonigral distribution of a fluorescent reporter following intracerebral delivery of genome editors. Front Bioeng Biotechnol. 2023;11:1237613 pubmed publisher
	Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher
	Shadfar S, Khanal S, Bohara G, Kim G, Sadigh Eteghad S, Ghavami S, et al. Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity. Mol Neurobiol. 2022;59:5874-5890 pubmed publisher
	Davis H, Paterson D, Herring N. Post-Ganglionic Sympathetic Neurons can Directly Sense Raised Extracellular Na+ via SCN7a/Nax. Front Physiol. 2022;13:931094 pubmed publisher
	Xin J, Shan W, Li J, Yu H, Zuo Z. Activation of the Lateral Habenula-Ventral Tegmental Area Neural Circuit Contributes to Postoperative Cognitive Dysfunction in Mice. Adv Sci (Weinh). 2022;:e2202228 pubmed publisher
	Liu Y, Jean Richard Dit Bressel P, Yau J, Willing A, Prasad A, Power J, et al. The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking. J Neurosci. 2020;40:6409-6427 pubmed publisher
	Calkoen E, Vicente Steijn R, Hahurij N, van Munsteren C, Roest A, DeRuiter M, et al. Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling. Int J Cardiol. 2015;183:249-57 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tyrosine Hydroxylase Polyclonal Antibody

Catalog # :

PA1-4679

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Sheep

Reactivity :

Human, Many, Mouse, Rat

Applications :

Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Species :

Human, Many, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase

more info or order :

Invitrogen product webpage