GABRA1 Polyclonal Antibody | Invitrogen PA1-4658 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GABRA1 Polyclonal Antibody

catalog :

PA1-4658

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; loading ...; fig s4b	Sierra Valdez F, Ruiz Suárez J, Delint Ramirez I. Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors. Biochim Biophys Acta. 2016;1858:2603-2610 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GABRA1 Polyclonal Antibody

Catalog # :

PA1-4658

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

Immunohistochemistry: 1:100, Western Blot: 1:500-1:1,000

Species :

Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.

Immunogen :

Fusion protein from the cytoplasmic loop of the alpha 1 subunit of rat GABRA1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 1:100, Western Blot: 1:500-1:1,000

Aliases :

ECA4; EIEE19; EJM; EJM5; GABA alpha subunit; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABAA alpha 1; GABAAR alpha1; GABRA 1; GABRA1; Gabra-1; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor alpha 1 variant 1; gamma-aminobutyric acid A receptor alpha 1 variant 2; gamma-aminobutyric acid A receptor alpha 1 variant 3; gamma-aminobutyric acid A receptor alpha 1 variant 4; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid receptor subunit alpha-1-like; gamma-aminobutyric acid type A receptor alpha1 subunit; gamma-aminobutyric acid type A receptor subunit alpha1; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-1

more info or order :

Invitrogen product webpage