This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
LC3B Polyclonal Antibody
catalog :
PA1-46286
quantity :
100 uL
price :
US 562.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, bovine, pigs , zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 24
Reference
Duan J, Zhang Q, Zhu J, Lu J. Curcumin affects autophagy of prolactinoma cells by upregulating miR-206 to exert antitumor effects. J Biochem Mol Toxicol. 2024;38:e23734 pubmed publisher
Varland S, Silva R, Kjos xe5 s I, Faustino A, Bogaert A, Billmann M, et al. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nat Commun. 2023;14:6774 pubmed publisher
Nasrah S, Radi A, Daberkow J, Hummler H, Weber S, Seaayfan E, et al. MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway. Int J Mol Sci. 2023;24: pubmed publisher
El Maraghy S, Reda A, Essam R, Kortam M. The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism. Inflammopharmacology. 2023;31:2701-2717 pubmed publisher
Haney M, P xe1 lovics R, Munson C, Long C, Johansson P, Yip O, et al. APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia. bioRxiv. 2023;: pubmed publisher
El Latif A, Rabie M, Sayed R, Fattah M, Kenawy S. Inosine attenuates rotenone-induced Parkinson's disease in rats by alleviating the imbalance between autophagy and apoptosis. Drug Dev Res. 2023;84:1159-1174 pubmed publisher
Masson J, Badran G, Domdom M, Gherardi R, Mograbi B, Authier F, et al. Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant. Sci Rep. 2023;13:3198 pubmed publisher
Hernandez A, Sonavane M, Smith K, Seiger J, Migaud M, Gassman N. Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells. PLoS ONE. 2022;17:e0278516 pubmed publisher
Ridlo M, Kim E, Kim E, Kim G. The Improvement of Porcine In Vitro Embryo Development through Regulating Autophagy by miRNA-143 Inhibition. Animals (Basel). 2022;12: pubmed publisher
Zhang X, Li X, Wang Y, Chen Y, Hu Y, Guo C, et al. Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis. JCI Insight. 2022;7: pubmed publisher
Chen L, Zhu L, Lu X, Ming X, Yang B. TRPM2 regulates autophagy to participate in hepatitis B virus replication. J Viral Hepat. 2022;29:627-636 pubmed publisher
Thery F, Martina L, Asselman C, Zhang Y, Vessely M, Repo H, et al. Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity. Nat Commun. 2021;12:5772 pubmed publisher
Ashley R, Runyan C, Maestas M, Trigo E, Silver G. Inhibition of the C-X-C Motif Chemokine 12 (CXCL12) and Its Receptor CXCR4 Reduces Utero-Placental Expression of the VEGF System and Increases Utero-Placental Autophagy. Front Vet Sci. 2021;8:650687 pubmed publisher
Soman S, Tingle D, Dagda R, Torres M, Dagda M, Dagda R. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation. J Neurosci Res. 2021;99:2134-2155 pubmed publisher
Hayat F, Sonavane M, Makarov M, Trammell S, McPherson P, Gassman N, et al. The Biochemical Pathways of Nicotinamide-Derived Pyridones. Int J Mol Sci. 2021;22: pubmed publisher
Zielke S, Kardo S, Zein L, Mari M, Covarrubias Pinto A, Kinzler M, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2020;:1-17 pubmed publisher
Masson J, Blanchet B, Periou B, Authier F, Mograbi B, Gherardi R, et al. Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?. Biomedicines. 2020;8: pubmed publisher
Kinzler M, Zielke S, Kardo S, Meyer N, Kogel D, van Wijk S, et al. STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Sci Rep. 2020;10:687 pubmed publisher
McIntosh S, Maxam C, Maestas M, Quinn K, Ashley R. Intrauterine inhibition of chemokine receptor 4 signaling modulates local and systemic inflammation in ovine pregnancy. Am J Reprod Immunol. 2019;82:e13181 pubmed publisher
Runyan C, McIntosh S, Maestas M, Quinn K, Boren B, Ashley R. CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium†. Biol Reprod. 2019;101:102-111 pubmed publisher
Izdebska M, Hałas Wiśniewska M, Zielińska W, Klimaszewska Wisniewska A, Grzanka D, Gagat M. Lidocaine induces protective autophagy in rat C6 glioma cell line. Int J Oncol. 2019;54:1099-1111 pubmed publisher
Zielke S, Meyer N, Mari M, Abou El Ardat K, Reggiori F, van Wijk S, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994 pubmed publisher
Marsh N, Wareham A, White B, Miskiewicz E, Landry J, MacPhee D. HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy. Biol Reprod. 2015;92:131 pubmed publisher
Varga M, Fodor E, Vellai T. Autophagy in zebrafish. Methods. 2015;75:172-80 pubmed publisher
product information
Product Type :
Antibody
Product Name :
LC3B Polyclonal Antibody
Catalog # :
PA1-46286
Quantity :
100 uL
Price :
US 562.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Bacteria, Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish
Applications :
Flow Cytometry: 1:200, Immunocytochemistry: 0.1-2 ug/mL, Immunohistochemistry (Frozen): 1:400, Immunohistochemistry (Paraffin): 1:200-1:400, Immunomicroscopy: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
Species :
Bacteria, Bovine, Canine, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
Immunogen :
N-terminal region of the human LC3, isoform B protein.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:200, Immunocytochemistry: 0.1-2 ug/mL, Immunohistochemistry (Frozen): 1:400, Immunohistochemistry (Paraffin): 1:200-1:400, Immunomicroscopy: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
Aliases :
1010001C15Rik; Atg8; ATG8E; ATG8F; ATG8G; Autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3; LC3 beta; LC3A; LC3B; light chain 3; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Map1alc3; MAP1BLC3; MAP1LC3; MAP1LC3A; MAP1LC3B; MAP1LC3B2; MAP1LC3B-a; microtubule associated protein 1 light chain 3 beta; microtubule associated protein 1 light chain 3 beta 2; microtubule-associated protein 1 light chain 3; microtubule-associated protein 1 light chain 3 beta; microtubule-associated protein 1 light chain 3 beta 2; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3 beta 2; Microtubule-associated proteins 1A/1B light chain 3B; Microtubule-associated proteins 1A/1B light chain 3B-like; Microtubule-associated proteins 1A/1B light chain 3B-like protein; Mpl3; RP11-346K17.1; wu:fb60g11; zbs559; zgc:56434
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA