STIM1 Polyclonal Antibody | Invitrogen PA1-46217 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

STIM1 Polyclonal Antibody

catalog :

PA1-46217

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunocytochemistry

citations: 2

Reference
Tandl D, Sponagel T, Alansary D, Fuck S, Smit T, Hehlgans S, et al. X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation. J Gen Physiol. 2022;154: pubmed publisher
Callaghan N, Lee S, Hadipour Lakmehsari S, Lee X, Ahsan Siraj M, Driouchi A, et al. Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes. Commun Biol. 2020;3:229 pubmed publisher

product information

Product Type :

Antibody

Product Name :

STIM1 Polyclonal Antibody

Catalog # :

PA1-46217

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Canine, Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Western Blot: 1:1,000

Species :

Bovine, Canine, Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.

Immunogen :

Synthetic peptide made to a C-terminal region with residues 600-685 of the human protein.[Uniprot#Q13586]

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Western Blot: 1:1,000

Aliases :

D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1