PGP9.5 Polyclonal Antibody | Invitrogen PA1-46204 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PGP9.5 Polyclonal Antibody

catalog :

PA1-46204

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine, pigs , domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 2

Reference
Jalil M, Coverdell T, Gutierrez V, Crook M, Shi J, Stornetta D, et al. Molecular Disambiguation of Heart Rate Control by the Nucleus Ambiguus. bioRxiv. 2023;: pubmed publisher
Hirth M, Xie Y, H xf6 per C, Prats A, Hackert T, Ebert M, et al. Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being. Cells. 2022;11: pubmed publisher

product information

Product Type :

Antibody

Product Name :

PGP9.5 Polyclonal Antibody

Catalog # :

PA1-46204

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

IgY fraction

Host :

Chicken

Reactivity :

Bovine, Equine, Human, Mouse, Porcine, Rat

Applications :

Immunocytochemistry: 1:1,000, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: 1:10,000

Species :

Bovine, Equine, Human, Mouse, Porcine, Rat

Isotype :

IgY

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.

Immunogen :

Recombinant full length human UCHL1 purified from E. coli.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,000, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: 1:10,000

Aliases :

AW822034; C88048; epididymis luminal protein 117; epididymis secretory protein Li 53; gad; gracile axonal dystrophy; HEL-117; HEL-S-53; MGC133697 protein; NDGOA; neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; PARK5; PGP 9.5; PGP9.5; PGP95; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal esterase; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxy-terminal hydrolase L1; ubiquitin C-terminal hydrolase; ubiquitin C-terminal hydrolase 1; ubiquitin C-terminal hydrolase L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1; UCHL; UCHL1; UCH-L1; UCHL-1