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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
WWTR1 Polyclonal Antibody
catalog :
PA1-46190
quantity :
100 µL
price :
US 514
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig s5d
Nardone G, Oliver De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat Commun. 2017;8:15321 pubmed publisher
product information
Product Type :
Antibody
Product Name :
WWTR1 Polyclonal Antibody
Catalog # :
PA1-46190
Quantity :
100 µL
Price :
US 514
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:500, Immunoprecipitation: 1:100, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1:1,000-1:5,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20°C or -80°C if preferred
Description :
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
Immunogen :
Human TAZ protein.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:500, Immunoprecipitation: 1:100, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1:1,000-1:5,000
Aliases :
2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA