NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

antibody

WWTR1 Polyclonal Antibody

PA1-46190

100 µL

US 514

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay

WWTR1 Polyclonal Antibody

PA1-46190

100 µL

US 514

Polyclonal

Antigen affinity chromatography

Rabbit

Human, Mouse, Rat

ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:500, Immunoprecipitation: 1:100, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1:1,000-1:5,000

Human, Mouse, Rat

IgG

-20°C or -80°C if preferred

WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.

Human TAZ protein.

Liquid

ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:500, Immunoprecipitation: 1:100, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1:1,000-1:5,000

2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1