YAP1 Polyclonal Antibody | Invitrogen PA1-46189 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

YAP1 Polyclonal Antibody

catalog :

PA1-46189

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 5	Ma W, Jiang J, Li M, Wang H, Zhang H, He X, et al. The clinical significance of forkhead box protein A1 and its role in colorectal cancer. Mol Med Rep. 2016;14:2625-31 pubmed publisher
	Ma N, Wibowo Y, Wirtz P, Baltus D, Wieland T, Jansen S. Tankyrase inhibition interferes with junction remodeling, induces leakiness, and disturbs YAP1/TAZ signaling in the endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2023;: pubmed publisher
	Owen N, Toms M, Tian Y, Toualbi L, Richardson R, Young R, et al. Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina. J Pathol. 2023;259:441-454 pubmed publisher
	Wu M, Matar D, Yu Z, Chen Z, Knoedler S, Ng B, et al. Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing. Pharmaceutics. 2022;14: pubmed publisher
	La Verde G, Artiola V, Pugliese M, La Commara M, Arrichiello C, Muto P, et al. Radiation therapy affects YAP expression and intracellular localization by modulating lamin A/C levels in breast cancer. Front Bioeng Biotechnol. 2022;10:969004 pubmed publisher
	Maremonti M, Panzetta V, Dannhauser D, Netti P, Causa F. Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses. J R Soc Interface. 2022;19:20210880 pubmed publisher
	Geiger F, Schnitzler L, Brugger M, Westerhausen C, Engelke H. Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation. PLoS ONE. 2022;17:e0264571 pubmed publisher
	Canu V, Donzelli S, Sacconi A, Lo Sardo F, Pulito C, Bossel N, et al. Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation. Cell Death Differ. 2021;28:1493-1511 pubmed publisher
	Li H, Kan B, Song L, Liu Y, Jian X. Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis. J Int Med Res. 2020;48:300060520905425 pubmed publisher
	Ganci F, Pulito C, Valsoni S, Sacconi A, Turco C, Vahabi M, et al. PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2020;26:2956-2971 pubmed publisher
	Han Y, Zhang L, Yu X, Wang S, Xu C, Yin H, et al. Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway. Cell Death Dis. 2019;10:374 pubmed publisher
	McGowan M, Kleinberg L, Halvorsen A, Helland A, Brustugun O. NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors. Genes Cancer. 2017;8:497-504 pubmed publisher

product information

Product Type :

Antibody

Product Name :

YAP1 Polyclonal Antibody

Catalog # :

PA1-46189

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Human, Mouse, Rat, Zebrafish

Applications :

ChIP Assay: 1.5 ug/10^6 cells, Immunocytochemistry: 1:500, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:200, Immunoprecipitation: 2-10 ug, Western Blot: 1:1,000

Species :

Canine, Human, Mouse, Rat, Zebrafish

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

Immunogen :

Recombinant YAP1 protein expressed in bacteria.

Format :

Liquid

Applications w/Dilutions :

Aliases :

65 kDa Yes-associated protein; AI325207; cb194; CH211-181P1.5-001; COB1; Protein yorkie homolog; sb:cb194; si:ch211-181p1.5; si:dkey-3b8.3; transcriptional coactivator YAP1; wu:fc18c04; yap; Yap1; YAP2; Yap65; Yes associated protein 1; Yes1 associated transcriptional regulator; yes-associated protein 1; yes-associated protein 2; yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; Yki; Yorkie; yorkie homolog; zgc:158380; zYAP

more info or order :

Invitrogen product webpage