53BP1 Polyclonal Antibody | Invitrogen PA1-46147 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

53BP1 Polyclonal Antibody

catalog :

PA1-46147

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, proximity ligation assay

citations: 2

Reference
Adrian G, Konradsson E, Beyer S, Wittrup A, Butterworth K, McMahon S, et al. Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions. Front Oncol. 2021;11:686142 pubmed publisher
Dulong J, Kouakou C, Mesloub Y, Rorteau J, Moratille S, Chevalier F, et al. NFATC2 Modulates Radiation Sensitivity in Dermal Fibroblasts From Patients With Severe Side Effects of Radiotherapy. Front Oncol. 2020;10:589168 pubmed publisher

product information

Product Type :

Antibody

Product Name :

53BP1 Polyclonal Antibody

Catalog # :

PA1-46147

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 2 - 5 ug/mL, Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: Assay-Dependent, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1:1,000-1:10,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Immunogen :

Human tumor protein p53-binding protein 1 encoded in exon 11, 12 and 19.

Format :

Liquid

Applications w/Dilutions :

Aliases :

53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1