FOXP3 Polyclonal Antibody | Invitrogen PA1-46126 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FOXP3 Polyclonal Antibody

catalog :

PA1-46126

quantity :

100 uL

price :

US 494.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig 1g	Li Z, Wang H, Zeng Q, Yan J, Hu Y, Li H, et al. p65/miR-23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma. Cancer Med. 2020;9:711-723 pubmed publisher
	Hamy A, Derosa L, Valdelièvre C, Yonekura S, Opolon P, Priour M, et al. Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer. Oncoimmunology. 2020;9:1677427 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FOXP3 Polyclonal Antibody

Catalog # :

PA1-46126

Quantity :

100 uL

Price :

US 494.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse, Rat

Applications :

Flow Cytometry: 1:8,000, Immunocytochemistry: 1:500, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: Assay-Dependent, Western Blot: 1:2,000

Species :

Bovine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

Immunogen :

A peptide containing amino acids 43-100 of mouse FOXP3

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:8,000, Immunocytochemistry: 1:500, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: Assay-Dependent, Western Blot: 1:2,000

Aliases :

AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID

more info or order :

Invitrogen product webpage