Humanin Polyclonal Antibody | Invitrogen PA1-41610 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Humanin Polyclonal Antibody

catalog :

PA1-41610

quantity :

100 uL

price :

US 460.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

citations: 2

Reference
Atali S, Dorandish S, Devos J, Williams A, Price D, Taylor J, et al. Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP. FEBS Open Bio. 2020;10:2805-2823 pubmed publisher
Price D, Dorandish S, Williams A, Iwaniec B, Stephens A, Marshall K, et al. Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3. Biochemistry. 2020;59:1981-2002 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Humanin Polyclonal Antibody

Catalog # :

PA1-41610

Quantity :

100 uL

Price :

US 460.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1:100-1:1,000, Western Blot: 1:2,000

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Humanin is a novel 24 A. A polypeptide identified in Alzheimer's disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

Immunogen :

Synthetic peptide corresponding to residues 12-24 of human humanin.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:100-1:1,000, Western Blot: 1:2,000

Aliases :

BCL2L4; HN1; Humanin-like 1; humanin-like protein 1; mitochondrially encoded 16S RNA; MTRNR2; MT-RNR2; MTRNR2L1; MT-RNR2-like 1; MTRNR2-like 1; MT-RNR2-like protein 1; RNR2