RIP3 Polyclonal Antibody | Invitrogen PA1-41533 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RIP3 Polyclonal Antibody

catalog :

PA1-41533

quantity :

100 ug

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 2

Reference
Simoes Eugénio M, Faurez F, Kara Ali G, Lagarrigue M, Uhart P, Bonnet M, et al. TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex. Front Mol Biosci. 2021;8:645134 pubmed publisher
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, et al. Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury. Cell Death Dis. 2017;8:e2904 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RIP3 Polyclonal Antibody

Catalog # :

PA1-41533

Quantity :

100 ug

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 1:20-1:500, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 3-7 ug/mL

Species :

Human, Non-human primate

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.

Immunogen :

Partial synthetic peptide corresponding to amino acids 497-518 of human RIPK3/RIP3

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:500, Immunohistochemistry (Paraffin): 10 ug/mL, Immunoprecipitation: Assay-Dependent, Western Blot: 3-7 ug/mL

Aliases :

2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3