This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TAB3 Polyclonal Antibody
catalog :
PA1-41489
quantity :
100 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, dogs
application :
western blot, immunocytochemistry
product information
Product Type :
Antibody
Product Name :
TAB3 Polyclonal Antibody
Catalog # :
PA1-41489
Quantity :
100 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Protein G
Host :
Rabbit
Reactivity :
Canine, Human, Mouse
Applications :
Immunocytochemistry: Assay-Dependent, Western Blot: 0.5-2 ug/mL
Species :
Canine, Human, Mouse
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Immunogen :
Synthetic peptide corresponding to residues 50-100 of human TAB3.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-Dependent, Western Blot: 0.5-2 ug/mL
Aliases :
4921526G09Rik; Kiaa4135; MAP3K7IP3; mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7-interacting protein 3; mKIAA4135; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; Tab3; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA