SOCS5 Polyclonal Antibody | Invitrogen PA1-41253 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SOCS5 Polyclonal Antibody

catalog :

PA1-41253

quantity :

200 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 2

Reference
Pandit M, Timilshina M, Gu Y, Acharya S, Chung Y, Seo S, et al. AMPK suppresses Th2 cell responses by repressing mTORC2. Exp Mol Med. 2022;54:1214-1224 pubmed publisher
Tsai Y, Kuo P, Hung W, Wu L, Wu P, Chang W, et al. Angpt2 Induces Mesangial Cell Apoptosis through the MicroRNA-33-5p-SOCS5 Loop in Diabetic Nephropathy. Mol Ther Nucleic Acids. 2018;13:543-555 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SOCS5 Polyclonal Antibody

Catalog # :

PA1-41253

Quantity :

200 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:500

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Immunogen :

Synthetic peptide corresponding to a portion of human SOCS5 protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:500

Aliases :

1810018L08Rik; CIS6; CIS-6; CISH5; CISH6; cytokine inducible SH2-containing protein 5; cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5; KIAA0671; mKIAA0671; RGD1564914; Socs5; SOCS-5; Suppressor of cytokine signaling 5