Anthrax Lethal Factor Polyclonal Antibody | Invitrogen PA1-41171 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Anthrax Lethal Factor Polyclonal Antibody

catalog :

PA1-41171

quantity :

200 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

anthrax bacterium

application :

western blot

citations: 1

Reference
Purde V, Kudryashova E, Heisler D, Shakya R, Kudryashov D. Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts. Proc Natl Acad Sci U S A. 2020;117:22090-22100 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Anthrax Lethal Factor Polyclonal Antibody

Catalog # :

PA1-41171

Quantity :

200 uL

Price :

US 474.00

Clonality :

Polyclonal

Host :

Rabbit

Applications :

Western Blot: 1:1,000

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.

Immunogen :

Synthetic peptide corresponding ot residues 47-65 of Anthrax lethal factor.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

Anthrax LF