FIS1 Polyclonal Antibody | Invitrogen PA1-41082 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FIS1 Polyclonal Antibody

catalog :

PA1-41082

quantity :

200 µL

price :

US 450.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 5c	Zhao Y, Tian J, Sui S, Yuan X, Chen H, Qu C, et al. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Sci Rep. 2017;7:7169 pubmed publisher
	Axelrod C, Fealy C, Erickson M, Davuluri G, Fujioka H, Dantas W, et al. Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans. Metabolism. 2021;121:154803 pubmed publisher
	Douida A, Batista F, Boto P, Regdon Z, Robaszkiewicz A, Tar K. Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing. Int J Mol Sci. 2021;22: pubmed publisher
	Kim D, Sankaramoorthy A, Roy S. Downregulation of Drp1 and Fis1 Inhibits Mitochondrial Fission and Prevents High Glucose-Induced Apoptosis in Retinal Endothelial Cells. Cells. 2020;9: pubmed publisher
	Park J, Seo J, Won J, Yeo H, Ahn Y, Kim K, et al. Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling. Exp Neurobiol. 2019;28:414-424 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FIS1 Polyclonal Antibody

Catalog # :

PA1-41082

Quantity :

200 µL

Price :

US 450.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Immunogen :

Synthetic peptide corresponding to residues 11-25 of human Fis1.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:500-1:1,000

Aliases :

2010003O14Rik; CGI-135; Fis1; fis1 {ECO:0000250; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); fission, mitochondrial 1; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; UniProtKB:Q9Y3D6}