UNG Polyclonal Antibody | Invitrogen PA1-41024 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

UNG Polyclonal Antibody

catalog :

PA1-41024

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

UNG Polyclonal Antibody

Catalog # :

PA1-41024

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Human, Mouse, Rabbit, Rat

Applications :

Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 2 ug/mL

Species :

Human, Mouse, Rabbit, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB. The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis. Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type. Additionally, the expression of UNG is cell cycle regulated. The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells. UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.

Immunogen :

Synthetic peptide corresponding to residues C(281) R H F S K T N E L L Q K S G K K P(298) of human UNG1 (NP 003353.1).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 2 ug/mL

Aliases :

DGU; DKFZp781L1143; HIGM4; HIGM5; UDG; UNG; Ung1; UNG15; UNG2; unga; uracil DNA glycosylase; uracil DNA glycosylase a; uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase isoform UNG1; uracil-DNA glycosylase isoform UNG2; uracil-DNA glycosylase nuclear isoform; zgc:56102