Cytokeratin 5 Polyclonal Antibody | Invitrogen PA1-37974 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cytokeratin 5 Polyclonal Antibody

catalog :

PA1-37974

quantity :

1 mL

price :

US 718.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 1c	Gomi K, Tang Y, Arbelaez V, Crystal R, Walters M. Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem Cell Rev. 2017;13:309-317 pubmed publisher
immunocytochemistry; human; 2 ug/ml; fig 2e	Gomi K, Staudt M, Salit J, Kaner R, Heldrich J, Rogalski A, et al. JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium. Stem Cell Rev. 2016;12:454-63 pubmed publisher
	Subramaniyan B, Gurung S, Bodas M, Moore A, Larabee J, Reuter D, et al. The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions. Viruses. 2023;15: pubmed publisher
	Xu X, Cai B, Liu Y, Liu R, Li J. MIR503HG silencing promotes endometrial stromal cell progression and metastasis and suppresses apoptosis in adenomyosis by activating the Wnt/β‑catenin pathway via targeting miR‑191. Exp Ther Med. 2023;25:117 pubmed publisher
	Naeimi Kararoudi M, Alsudayri A, Hill C, Elmas E, Sezgin Y, Thakkar A, et al. Assessment of Beta-2 Microglobulin Gene Edited Airway Epithelial Stem Cells as a treatment for Sulfur Mustard Inhalation. Front Genome Ed. 2022;4:781531 pubmed publisher
	Boecking C, Walentek P, Zlock L, Sun D, Wolters P, Ishikawa H, et al. A simple method to generate human airway epithelial organoids with externally orientated apical membranes. Am J Physiol Lung Cell Mol Physiol. 2022;322:L420-L437 pubmed publisher
	Bodas M, Subramaniyan B, Moore A, Metcalf J, Oca xf1 as S, Freeman W, et al. The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Cells. 2021;10: pubmed publisher
	Bodas M, Moore A, Subramaniyan B, Georgescu C, Wren J, Freeman W, et al. Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2021;64:426-440 pubmed publisher
	Haas M, Gómez Vázquez J, Sun D, Tran H, Brislinger M, Tasca A, et al. ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia. Cell Rep. 2019;28:3338-3352.e6 pubmed publisher
	Wang G, Lou H, Salit J, Leopold P, Driscoll S, Schymeinsky J, et al. Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Respir Res. 2019;20:196 pubmed publisher
	Ogawa F, Walters M, Shafquat A, O Beirne S, Kaner R, Mezey J, et al. Role of KRAS in regulating normal human airway basal cell differentiation. Respir Res. 2019;20:181 pubmed publisher
	Sun D, Tasca A, Haas M, Baltazar G, Harland R, Finkbeiner W, et al. Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia. Cells Tissues Organs. 2018;205:279-292 pubmed publisher
	Zhang H, Yang J, Walters M, Staudt M, Strulovici Barel Y, Salit J, et al. Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget. 2018;9:14324-14337 pubmed publisher
	Ding B, Gomi K, Rafii S, Crystal R, Walters M. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci. 2015;128:2983-8 pubmed publisher
	Gomi K, Arbelaez V, Crystal R, Walters M. Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS ONE. 2015;10:e0116507 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Cytokeratin 5 Polyclonal Antibody

Catalog # :

PA1-37974

Quantity :

1 mL

Price :

US 718.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Immunogen :

Synthetic peptide corresponding to C-terminus of human cytokeratin 5.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:100, Western Blot: 1:1,000

Aliases :

3300001P10Rik; 58 kDa cytokeratin; alpha keratin; AW146334; CK5; CK-5; ckii; ckii protein; cytokeratin 5; cytokeratin-5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin complex 2, basic, gene 5; keratin type II, tail domain; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 5; keratin 5; keratin-5; Krt2-5; KRT5; KRT5A; Sak57; Tfip8; tuftelin interacting protein 8; type II alpha-keratin IIA; type II cytokeratin; type-II keratin Kb5; wu:fb02h09; wu:fj02d02; wu:fk78b12; zfCKII

more info or order :

Invitrogen product webpage