SREBP2 Polyclonal Antibody | Invitrogen PA1-338 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SREBP2 Polyclonal Antibody

catalog :

PA1-338

quantity :

100 ug

price :

US 465.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:2000; fig 4b	Kim K, Kabra A, Kim D, Xue Y, Huang Y, Hou P, et al. KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Sci Adv. 2022;8:eabl4618 pubmed publisher
	Ariano C, Costanza F, Akman M, Riganti C, Cor xe0 D, Casanova E, et al. TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism. Cell Death Dis. 2023;14:314 pubmed publisher
	Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, et al. N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021;12:6314 pubmed publisher
	Trindade B, Ceglia S, Berthelette A, Raso F, Howley K, Muppidi J, et al. The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. Immunity. 2021;54:2273-2287.e6 pubmed publisher
	Bosc C, Broin N, Fanjul M, Saland E, Farge T, Courdy C, et al. Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites. Nat Commun. 2020;11:4056 pubmed publisher
	Fan Q, Yin X, Rababa h A, Díaz Díaz A, Wijaya C, Singh S, et al. Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis. Am J Physiol Heart Circ Physiol. 2019;317:H793-H810 pubmed publisher
	Moon S, Huang C, Houlihan S, Regunath K, Freed Pastor W, Morris J, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019;176:564-580.e19 pubmed publisher
	Borude P, Bhushan B, Gunewardena S, Akakpo J, Jaeschke H, Apte U. Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose. Am J Pathol. 2018;188:1406-1418 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SREBP2 Polyclonal Antibody

Catalog # :

PA1-338

Quantity :

100 ug

Price :

US 465.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Immunogen :

Synthetic peptide corresponding to residues A(843) I S W L Q G D D A A V R S H(857) of rat SREBP 2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:200, Western Blot: 1:100-1:1,000

Aliases :

AI608257; bHLHd2; Class D basic helix-loop-helix protein 2; EMBL:AAI01903.1}; lop13; nuc; Processed sterol regulatory element-binding protein 2; srebf2; srebf2 {ECO:0000312; Srebf2_retired; SREBP2; SREBP-2; SREBP2gc; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; sterol regulatory element binding transcription factor 2; sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2; zgc:158371

more info or order :

Invitrogen product webpage