SREBP1 Polyclonal Antibody | Invitrogen PA1-337 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SREBP1 Polyclonal Antibody

catalog :

PA1-337

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; loading ...; fig 5c	Zhao Y, Li W, Zhang D. Gycyrrhizic acid alleviates atherosclerotic lesions in rats with diabetes mellitus. Mol Med Rep. 2021;24: pubmed publisher
	Rungsa P, San H, Sritularak B, B xf6 ttcher C, Prompetchara E, Chaotham C, et al. Inhibitory Effect of Isopanduratin A on Adipogenesis: A Study of Possible Mechanisms. Foods. 2023;12: pubmed publisher
	Lu Z, Sun G, Pan X, Qu X, Yang P, Chen Z, et al. BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model. Front Pharmacol. 2022;13:1025551 pubmed publisher
	Lee S, Chung K, Son S, Lee S, Jang D, Lee J, et al. A Botanical Mixture Consisting of Inula japonica and Potentilla chinensis Relieves Obesity via the AMPK Signaling Pathway in 3T3-L1 Adipocytes and HFD-Fed Obese Mice. Nutrients. 2022;14: pubmed publisher
	Haas M, Naem E, Almdallaleh S, Mooradian A. The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159155 pubmed publisher
	Sun M, Beier F. Liver X Receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes. Osteoarthr Cartil Open. 2020;2:100030 pubmed publisher
	Pang B, Zhu Z, Xiao C, Luo Y, Fang H, Bai Y, et al. Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis. Front Cell Dev Biol. 2021;9:779257 pubmed publisher
	Liu B, Tang Y, Song Z, Ge J. Polygonatum sibiricum F. Delaroche polysaccharide ameliorates HFD‑induced mouse obesity via regulation of lipid metabolism and inflammatory response. Mol Med Rep. 2021;24: pubmed publisher
	Tsai C, Chen Y, Yu H, Huang L, Tain Y, Lin I, et al. Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice. Lipids Health Dis. 2020;19:105 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SREBP1 Polyclonal Antibody

Catalog # :

PA1-337

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50-1:500, Western Blot: 1:500-1:5,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

Immunogen :

Synthetic peptide corresponding to residues M(32) L Q L I N N Q D S D F P G L F(47) of mouse SREBP 1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:500, Western Blot: 1:500-1:5,000

Aliases :

ADD1; ADD-1; Adipocyte determination- and differentiation-dependent factor 1; bHLHd1; Class D basic helix-loop-helix protein 1; D630008H06; I79_010155; nt-SREBP1; Processed sterol regulatory element-binding protein 1; SREBF1; SREBP1; SREBP-1; SREBP1a; SREBP-1a; SREBP1c; SREBP-1c; sterol regulatory element binding protein 1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; sterol regulatory element binding-protein 1; sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1

more info or order :

Invitrogen product webpage