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antibody

SR-BI/SR-BII Polyclonal Antibody

PA1-32415

100 uL

US 514.00

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

SR-BI/SR-BII Polyclonal Antibody

PA1-32415

100 uL

US 514.00

Polyclonal

Rabbit

Human, Mouse, Rat

Flow Cytometry: 1:400, Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Human, Mouse, Rat

IgG

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Synthetic peptide from the extracellular domain (residues 230-380) of Scavenger Receptor-BI/BII was expressed as two tandem copies in bacteria using the pET system.

Liquid

Flow Cytometry: 1:400, Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: 1:100, Western Blot: 1:1,000

85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; 9330185J12Rik; AI120173; AMRF; CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 1; CD36 antigen-like 2; CD36L1; CD36L2; Cla1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; D5Ertd460e; EPM4; HDL QTL 1; Hdlq1; HDLQTL6; Hlb398; HLGP85; LGP85; LIMP II; LIMP2; LIMP-2; LIMPII; lysosome membrane protein 2; Lysosome membrane protein II; MLGP85; mSR-BI; Scarb1; Scarb2; scavanger receptor class B type 1; scavenger receptor b1; scavenger receptor class B member 1; Scavenger receptor class B member 2; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B, member 2; scavenger receptor class B1; SRB1; SR-B1; SR-B1/B2; SRBI; SR-BI; SR-BI/BII; SR-BII