OGG1 Polyclonal Antibody | Invitrogen PA1-31402 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

OGG1 Polyclonal Antibody

catalog :

PA1-31402

quantity :

100 uL

price :

US 522.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 4

Reference
Tanner L, Single A, Bhongir R, Heusel M, Mohanty T, Karlsson C, et al. Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nat Commun. 2023;14:643 pubmed publisher
Ramdzan Z, Ginjala V, Pinder J, Chung D, Donovan C, Kaur S, et al. The DNA repair function of CUX1 contributes to radioresistance. Oncotarget. 2017;8:19021-19038 pubmed publisher
Kaur S, Coulombe Y, Ramdzan Z, Leduy L, Masson J, Nepveu A. Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair. J Biol Chem. 2016;291:22769-22780 pubmed
Pal R, Ramdzan Z, Kaur S, Duquette P, Marcotte R, Leduy L, et al. CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage. J Biol Chem. 2015;290:22520-31 pubmed publisher

product information

Product Type :

Antibody

Product Name :

OGG1 Polyclonal Antibody

Catalog # :

PA1-31402

Quantity :

100 uL

Price :

US 522.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Frozen): 1:25-1:100, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 1:10-1:500, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.

Immunogen :

A peptide derived from human Ogg1 (within amino acids 1-100) (UniProt# O15527)

Format :

Liquid

Applications w/Dilutions :

Aliases :

8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; Mmh; MUTM; N-glycosylase/DNA lyase; OGG1; OGG1 type 1f; OGH1