product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Estrogen Receptor beta Polyclonal Antibody
catalog :
PA1-311
quantity :
50 µg
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
hamsters, human, mouse, rat, domestic sheep
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
Invitrogen product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:3000; loading ...; fig 4b
Kim H, Park J, Leem H, Cho M, Yoon J, Maeng H, et al. Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress. Int J Mol Sci. 2019;20: pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 3b
Yuan B, Yang J, Dubeau L, Hu Y, Li R. A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021;9:649087 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000; loading ...; fig 5d
Helle J, Keiler A, Zierau O, Dörfelt P, Vollmer G, Lehmann L, et al. Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17?-estradiol regulated mRNA transcriptome of the rat uterus. J Steroid Biochem Mol Biol. 2017;171:133-143 pubmed publisher
  • immunohistochemistry - paraffin section; hamsters; loading ...; fig 3
  • western blot; hamsters; 1:600; loading ...; fig 4a
Kumar R, Yadav A, Pakrasi P. Expression of ER-? and ER-? during peri-implantation period in uterus is essential for implantation and decidualization in golden hamster. Life Sci. 2017;170:115-122 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 2
  • western blot; human; fig 1
Hagberg Thulin M, Nilsson M, Thulin P, Céraline J, Ohlsson C, Damber J, et al. Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis. Mol Cell Endocrinol. 2016;422:182-191 pubmed publisher
Zhu Y, Liu Z, Gui L, Yun W, Mao C, Deng R, et al. Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer. NPJ Breast Cancer. 2023;9:34 pubmed publisher
Ng A, Zhang S, Mak V, Zhou Y, Yuen Y, Sharma R, et al. AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance. Cell Rep. 2022;41:111821 pubmed publisher
Chang K, Su Y, Tsai Y, Lan K, Hsuuw Y, Kang H, et al. High levels estradiol affect blastocyst implantation and post-implantation development directly in mice. Biomed J. 2022;45:179-189 pubmed publisher
Bunma T, Kanjanaruch C, Kogram N, Uriyapongson S, Khanthusaeng V, Navanukraw C. Effects of FSH treatment and withdrawal during proestrus on uterine proliferation and steroid hormone receptor expression in beef heifers. Anim Sci J. 2021;92:e13621 pubmed publisher
Warfvinge K, Krause D, Maddahi A, Edvinsson J, Edvinsson L, Haanes K. Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects. J Headache Pain. 2020;21:131 pubmed publisher
Satirapod C, Wang N, MacDonald J, Sun M, Woods D, Tilly J. Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging. Aging (Albany NY). 2020;12:7313-7333 pubmed publisher
Ichii O, Nakamura T, Irie T, Kouguchi H, Sotozaki K, Horino T, et al. Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats. Exp Biol Med (Maywood). 2018;243:418-427 pubmed publisher
Kim H, Ham S, Lee J, Jo A, Lee G, Lee Y, et al. Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models. Oncotarget. 2017;8:106721-106739 pubmed publisher
Cooke P, Nanjappa M, Ko C, Prins G, Hess R. Estrogens in Male Physiology. Physiol Rev. 2017;97:995-1043 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Estrogen Receptor beta Polyclonal Antibody
Catalog # :
PA1-311
Quantity :
50 µg
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Non-human primate, Ovine, Rat
Applications :
Gel Shift: 1 µg/mL, Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 1 µg/mL, Western Blot: 1 µg/mL
Species :
Human, Mouse, Non-human primate, Ovine, Rat
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Immunogen :
Synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat ER beta.
Format :
Liquid
Applications w/Dilutions :
Gel Shift: 1 µg/mL, Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 1 µg/mL, Western Blot: 1 µg/mL
Aliases :
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA