product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Estrogen Receptor beta Polyclonal Antibody
catalog :
PA1-310B
quantity :
100 ug
price :
US 520.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 3a
Youssef S, El Khateeb E, Aly D, Moussa M. Striae distensae: Immunohistochemical assessment of hormone receptors in multigravida and nulligravida. J Cosmet Dermatol. 2017;16:279-286 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig 6a
Bruner Tran K, Duleba A, Taylor H, Osteen K. Developmental Toxicant Exposure Is Associated with Transgenerational Adenomyosis in a Murine Model. Biol Reprod. 2016;95:73 pubmed publisher
  • western blot; human; 1:100; fig 4
Peretz J, Pekosz A, Lane A, Klein S. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. Am J Physiol Lung Cell Mol Physiol. 2016;310:L415-25 pubmed publisher
Itoh N, Itoh Y, Meyer C, Suen T, Cortez Delgado D, Rivera Lomeli M, et al. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nat Commun. 2023;14:6044 pubmed publisher
Kallamadi P, Esari D, Addi U, Kesavan R, Putcha U, Nagini S, et al. Obesity Associated with Prediabetes Increases the Risk of Breast Cancer Development and Progression-A Study on an Obese Rat Model with Impaired Glucose Tolerance. Int J Mol Sci. 2023;24: pubmed publisher
Park D, Yoon J, Choi B, Lee Y, Ha I. Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model. Nutrients. 2023;15: pubmed publisher
Smiley C, Pate B, Bouknight S, Francis M, Nowicki A, Harrington E, et al. Estrogen receptor beta in the central amygdala regulates the deleterious behavioral and neuronal consequences of repeated social stress in female rats. Neurobiol Stress. 2023;23:100531 pubmed publisher
Black A, Haskins J, Pozzi A, Clark A. Sexual dimorphism in reactive oxygen species production and a role for integrin α1β1 in estrogen receptor α and β expression in articular cartilage. J Orthop Surg Res. 2023;18:170 pubmed publisher
Shin H, Yang W, Chay D, Lee E, Chung J, Kim H, et al. Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma. Mol Oncol. 2020;: pubmed publisher
Zhou X, Yang X, Zheng Y, Qin Z, Sha W, Chen G, et al. Jie-Yu Pill, A Proprietary Herbal Medicine, Ameliorates Mood Disorder-Like Behavior and Cognitive Impairment in Estrogen-Deprived Mice Exposed to Chronic Unpredictable Mild Stress: Implication for a Potential Therapy of Menopause Syndrome. Front Psychiatry. 2020;11:579995 pubmed publisher
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, et al. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol. 2020;26:1601-1612 pubmed publisher
Balit T, Abdel Wahhab M, Radenahmad N. Young Coconut Juice Reduces Some Histopathological Changes Associated with Alzheimer's Disease through the Modulation of Estrogen Receptors in Orchidectomized Rat Brains. J Aging Res. 2019;2019:7416419 pubmed publisher
Kim K, Cho Y, Lee J, Jeong H, Lee Y, Kim S, et al. Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum. Sci Rep. 2019;9:11167 pubmed publisher
Alofe O, Kisanga E, Inayat Hussain S, Fukumura M, Garcia Milian R, Perera L, et al. Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. Environ Int. 2019;131:104969 pubmed publisher
Ye Z, Cudmore R, Linden D. Estrogen-Dependent Functional Spine Dynamics in Neocortical Pyramidal Neurons of the Mouse. J Neurosci. 2019;39:4874-4888 pubmed publisher
Evola C, Hudson T, Huang L, Corbett A, Mayes D. Gender- and region-specific changes in estrogen signaling in aging rat brain mitochondria. Aging (Albany NY). 2018;10:2148-2169 pubmed publisher
Warns J, Marwarha G, Freking N, Ghribi O. 27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines. Biochimie. 2018;153:171-180 pubmed publisher
Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed publisher
Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Åkerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed publisher
Harvey C, Chen J, Bagnell C, Uzumcu M. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. Reprod Toxicol. 2015;51:72-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Estrogen Receptor beta Polyclonal Antibody
Catalog # :
PA1-310B
Quantity :
100 ug
Price :
US 520.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1 ug/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
Immunogen :
Synthetic peptide corresponding to residues C(467) S S T E D S K N K E S S Q N L Q S Q(485) of rat ER beta.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1 ug/mL
Aliases :
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA