p19ARF Polyclonal Antibody | Invitrogen PA1-30670 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p19ARF Polyclonal Antibody

catalog :

PA1-30670

quantity :

100 uL

price :

US 522.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 7

Reference
Dhanabalan K, Dravid A, Agarwal S, Sharath R, Padmanabhan A, Agarwal R. Intra-articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis. Bioeng Transl Med. 2023;8:e10298 pubmed publisher
Zhu M, Min S, Mao X, Zhou Y, Zhang Y, Li W, et al. Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis. Int J Oral Sci. 2022;14:29 pubmed publisher
Kletzien H, Kelm Nelson C, Wang S, Suzuki M, Connor N. Myogenic marker expression as a function of age and exercise-based therapy in the tongue. Exp Gerontol. 2020;142:111104 pubmed publisher
Du S, Shao J, Qi Y, Liu X, Liu J, Zhang F. Long non-coding RNA ANRIL alleviates H2O2-induced injury by up-regulating microRNA-21 in human lens epithelial cells. Aging (Albany NY). 2020;12:6543-6557 pubmed publisher
Philip B, Yu D, Silvis M, Shin C, Robinson J, Robinson G, et al. Mutant IDH1 Promotes Glioma Formation In Vivo. Cell Rep. 2018;23:1553-1564 pubmed publisher
Al Khalaf H, Nallar S, Kalvakolanu D, Aboussekhra A. p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. Mol Carcinog. 2017;56:1687-1702 pubmed publisher
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med. 2015;21:62-70 pubmed publisher

product information

Product Type :

Antibody

Product Name :

p19ARF Polyclonal Antibody

Catalog # :

PA1-30670

Quantity :

100 uL

Price :

US 522.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

ELISA: 1:100-1:2,000, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Frozen): 1 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 2 ug/mL

Species :

Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.

Immunogen :

Synthetic peptide conjugated to KLH, derived from a sequence within residues 50-150 of mouse p19ARF.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:100-1:2,000, Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Frozen): 1 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 2 ug/mL

Aliases :

Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; INK4; INK4A; Ink4a/Arf; INK4a-ARF; LOC100764983; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16INK4A; p16-INK4a; P19; p19 ; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF