Leptin Receptor Polyclonal Antibody | Invitrogen PA1-28843 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Leptin Receptor Polyclonal Antibody

catalog :

PA1-28843

quantity :

50 ug

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

citations: 1

Reference
PedrÃ³s I, Petrov D, Artiach G, Abad S, Ramon Duaso C, Sureda F, et al. Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease. J Nutr Health Aging. 2015;19:403-12 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Leptin Receptor Polyclonal Antibody

Catalog # :

PA1-28843

Quantity :

50 ug

Price :

US 454.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

Western Blot: 1:1,800-1:2,200

Species :

Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

Immunogen :

Recombinant fragment - amino acids 25-208 of Mouse Leptin Receptor

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,800-1:2,200

Aliases :

B219; CD antigen CD295; CD295; CD295 antigen; db; diabetes; Fa; HuB219; HuB219.2; LEPR; LEP-R; Leprb; LEPRD; LEPROT; leptin receptor; Leptin receptor (fatty); leptin receptor gene-related protein; Modb1; OB receptor; obese-like; obl; Obr; OB-R; OB-RGRP