GLI2 Polyclonal Antibody | Invitrogen PA1-28838 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GLI2 Polyclonal Antibody

catalog :

PA1-28838

quantity :

50 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 3

Reference
Niesen J, Hermans Borgmeyer I, Kr xfc ger C, Schoof M, Modemann F, Sch xfc ller U. hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation. iScience. 2023;26:107501 pubmed publisher
Jiwani T, Kim J, Rosenblum N. Suppressor of fused controls cerebellum granule cell proliferation by suppressing Fgf8 and spatially regulating Gli proteins. Development. 2020;147: pubmed publisher
Posey K, Coustry F, Veerisetty A, Hossain M, Gambello M, Hecht J. Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies. Am J Pathol. 2019;189:132-146 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GLI2 Polyclonal Antibody

Catalog # :

PA1-28838

Quantity :

50 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: 1:15,000-1:60,000, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 2-20 ug/mL, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Immunogen :

synthetic peptide LRGAPSASRGSYTQQPR-C conjugated to KLH, corresponding to amino acids 1193-1209 of Mouse Gli2

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:15,000-1:60,000, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 2-20 ug/mL, Western Blot: 1:500-1:2,000

Aliases :

AW546128; CJS; GLI family zinc finger 2; GLI family zinc finger protein 2; GLI2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; HPE9; oncogene GLI2; PHS2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; Thp; THP1; THP2; zinc finger protein GLI2