8-Hydroxyguanosine Polyclonal Antibody | Invitrogen PA1-28031 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

8-Hydroxyguanosine Polyclonal Antibody

catalog :

PA1-28031

quantity :

50µL

price :

US 345

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

8-Hydroxyguanosine Polyclonal Antibody

Catalog # :

PA1-28031

Quantity :

50µL

Price :

US 345

Clonality :

Polyclonal

Host :

Goat

Reactivity :

Chemical

Applications :

ELISA: 1:100,000-1:250,000, Immunohistochemistry (Paraffin): 1:200

Species :

Chemical

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids. Production of reactive oxygen species (ROS) damage proteins, lipid membranes, and nucleic acids (DNA and RNA), all critical functional components of living cells. The progressive accumulation of unrepaired free radical damage over time is believed to be a major contributor to the aging process and to a variety of age-related chronic diseases. Generation of most free radicals is a 'side effect' of normal metabolic processes, especially mitochondrial production of ROS, including superoxide anion, hydrogen peroxide, and hydroxyl radical, coincident to oxidative metabolism. 8-OHG (marker of oxidative damage to RNA) was found in the cerebral cortex in three of six cases of neuropathologically examined autopsy of subacute sclerosing panencephalitis patients. Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. The concentration of 8-OHG in CSF in Parkinson's disease (PD) patients is approximately three-fold that in controls. The concentration of 8-OHG in CSF decreased significantly with the duration of disease. However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls. [National Center for Biotechnology Information. PubChem Compound Database; CID=65131]

Immunogen :

8-Hydroxyguanosine - conjugate.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:100,000-1:250,000, Immunohistochemistry (Paraffin): 1:200

Aliases :

C10H13N5O6, 8-Hydroxyguanosine, Hydroxyguanosine