Insulin Polyclonal Antibody | Invitrogen PA1-26938 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Insulin Polyclonal Antibody

catalog :

PA1-26938

quantity :

500 uL

price :

US 474.00

clonality :

polyclonal

host :

guinea-pigs

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:200; loading ...; fig 1c	D Addio F, Maestroni A, Assi E, Ben Nasr M, Amabile G, Usuelli V, et al. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nat Commun. 2022;13:684 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig st2	Zhu L, Almaca J, Dadi P, Hong H, Sakamoto W, Rossi M, et al. β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun. 2017;8:14295 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; fig 5 immunohistochemistry - paraffin section; mouse; 1:100; fig 5	Bruin J, Saber N, O Dwyer S, Fox J, Mojibian M, Arora P, et al. Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice. Diabetes. 2016;65:1297-309 pubmed publisher
	Lewis B, Mulka A, Mao L, Sharafieh R, Qiao Y, Kesserwan S, et al. Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models. J Diabetes Sci Technol. 2023;17:163-171 pubmed publisher
	Li F, Negi V, Yang P, Lee J, Ma K, Moulik M, et al. TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism. Nucleic Acids Res. 2022;50:12723-12738 pubmed publisher
	Chandra R, Aryal D, Douros J, Shahid R, Davis S, Campbell J, et al. Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia. PLoS ONE. 2022;17:e0270329 pubmed publisher
	Sona C, Yeh Y, Patsalos A, Halasz L, Yan X, Kononenko N, et al. Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes. JCI Insight. 2022;7: pubmed publisher
	Kesserwan S, Mao L, Sharafieh R, Kreutzer D, Klueh U. A pharmacological approach assessing the role of mast cells in insulin infusion site inflammation. Drug Deliv Transl Res. 2022;12:1711-1718 pubmed publisher
	Lane R, Wolters A, Giepmans B, Hoogenboom J. Integrated Array Tomography for 3D Correlative Light and Electron Microscopy. Front Mol Biosci. 2021;8:822232 pubmed publisher
	Dudek K, Osipovich A, Cartailler J, Gu G, Magnuson M. Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs. G3 (Bethesda). 2021;11: pubmed publisher
	Oppenl xe4 nder L, Palit S, Stemmer K, Greisle T, Sterr M, Salinno C, et al. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Mol Metab. 2021;54:101330 pubmed publisher
	Hart N, Weber C, Price N, Banuelos A, Schultz M, Huey B, et al. Insulinoma-derived pseudo-islets for diabetes research. Am J Physiol Cell Physiol. 2021;321:C247-C256 pubmed publisher
	Sobel J, Guay C, Elhanani O, Rodríguez Trejo A, Stoll L, Menoud V, et al. Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation. Sci Rep. 2021;11:8800 pubmed publisher
	Osipovich A, Dudek K, Greenfest Allen E, Cartailler J, Manduchi E, Potter Case L, et al. A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development. Development. 2021;148: pubmed publisher
	Cepeda J, Sekhar N, Han J, Xiong W, Zhang N, Yu L, et al. A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice. MAbs. 2020;12:1836714 pubmed publisher
	Canul Medina G, River xf3 n Negrete L, Past xe9 n Hidalgo K, Morales Castillo P, Garc xed a V xe1 zquez F, Fernandez Mejia C. Maternal adaptations of pancreatic islets and glucose metabolism after lactation. J Endocrinol. 2021;248:1-15 pubmed publisher
	Stephens C, Morrison R, McLaughlin M, Orr K, Tersey S, Scott Moncrieff J, et al. Oligomeric collagen as an encapsulation material for islet/β-cell replacement: effect of islet source, dose, implant site, and administration format. Am J Physiol Endocrinol Metab. 2020;319:E388-E400 pubmed publisher
	Marro B, Legrain S, Ware B, Oldstone M. Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model. JCI Insight. 2019;4: pubmed publisher
	Stephens C, Orr K, Acton A, Tersey S, Mirmira R, Considine R, et al. In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo. Am J Physiol Endocrinol Metab. 2018;315:E650-E661 pubmed publisher
	Chartoumpekis D, Yagishita Y, Fazzari M, Palliyaguru D, Rao U, Zaravinos A, et al. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight. 2018;3: pubmed publisher
	Kim D, Song L, Wang J, Wu H, Gu G, Sugi Y, et al. GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018;159:1062-1073 pubmed publisher
	Sisino G, Zhou A, Dahr N, Sabirsh A, Soundarapandian M, Perera R, et al. Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro. PLoS ONE. 2017;12:e0182371 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Insulin Polyclonal Antibody

Catalog # :

PA1-26938

Quantity :

500 uL

Price :

US 474.00

Clonality :

Polyclonal

Host :

Guinea Pig

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Frozen): 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Species :

Human, Mouse

Isotype :

IgG

Storage :

4 C, do not freeze

Description :

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Immunogen :

Full length human protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Frozen): 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:100

Aliases :

AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin

more info or order :

Invitrogen product webpage