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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
UCP1 Polyclonal Antibody
catalog :
PA1-24894
quantity :
100 µL
price :
US 496.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, cat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:5000; loading ...; fig 3h
Galmozzi A, Kok B, Kim A, Montenegro Burke J, Lee J, Spreafico R, et al. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. 2019;576:138-142 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Bayindir Buchhalter I, Wolff G, Lerch S, Sijmonsma T, Schuster M, Gronych J, et al. Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors. EMBO Mol Med. 2018;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Song Z, Xiaoli A, Zhang Q, Zhang Y, Yang E, Wang S, et al. Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein ?. J Biol Chem. 2017;292:8918-8932 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2e
Zou T, Chen D, Yang Q, Wang B, Zhu M, Nathanielsz P, et al. Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. J Physiol. 2017;595:1547-1562 pubmed publisher
  • western blot; human; 1:1000; fig 1
Müller S, Balaz M, Stefanicka P, Varga L, Amri E, Ukropec J, et al. Proteomic Analysis of Human Brown Adipose Tissue Reveals Utilization of Coupled and Uncoupled Energy Expenditure Pathways. Sci Rep. 2016;6:30030 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Klepac K, Kilić A, Gnad T, Brown L, Herrmann B, Wilderman A, et al. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016;7:10895 pubmed publisher
Opdebeeck B, Neven E, Maudsley S, Leysen H, Walter D, Geryl H, et al. A Proteomic Screen to Unravel the Molecular Pathways Associated with Warfarin-Induced or TNAP-Inhibited Arterial Calcification in Rats. Int J Mol Sci. 2023;24: pubmed publisher
Williams A, Long M, Kavanagh K. Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation. J Obes. 2023;2023:5651084 pubmed publisher
Jing X, Wu J, Dong C, Gao J, Seki T, Kim C, et al. COVID-19 instigates adipose browning and atrophy through VEGF in small mammals. Nat Metab. 2022;4:1674-1683 pubmed publisher
Garside J, Kavanagh K, Block M, Williams A, Branca R. Xenon-enhanced computed tomography assessment of brown adipose tissue distribution and perfusion in lean, obese, and diabetic primates. Obesity (Silver Spring). 2022;30:1831-1841 pubmed publisher
Song Z, Xiaoli A, Li Y, Siqin G, Wu T, Strich R, et al. The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. Mol Metab. 2022;64:101548 pubmed publisher
Weldenegodguad M, Pokharel K, Niiranen L, Soppela P, Ammosov I, Honkatukia M, et al. Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus). Commun Biol. 2021;4:1170 pubmed publisher
van Krieken P, Odermatt T, Borsigova M, Bluher M, Wueest S, Konrad D. Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling. Mol Metab. 2021;54:101341 pubmed publisher
Gonzalez Porras M, Stojkova K, Vaicik M, Pelowe A, Goddi A, Carmona A, et al. Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity. Sci Rep. 2021;11:5442 pubmed publisher
Liu X, Lu Y, Chen Z, Liu X, Hu W, Zheng L, et al. The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth. Mol Cancer Res. 2021;19:667-677 pubmed publisher
Liu H, Luo J, Guillory B, Chen J, Zang P, Yoeli J, et al. Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways. Oncotarget. 2020;11:3286-3302 pubmed publisher
Kundimi S, Kavungala K, Sinha S, Tayi V, Kundurthi N, Golakoti T, et al. Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats. Lipids Health Dis. 2020;19:198 pubmed publisher
Mooli R, Mukhi D, Watt M, Edmunds L, Xie B, Capooci J, et al. Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes. Metabolism. 2020;107:154225 pubmed publisher
Kovanicova Z, Kurdiova T, Balaz M, Stefanicka P, Varga L, Kulterer O, et al. Cold Exposure Distinctively Modulates Parathyroid and Thyroid Hormones in Cold-Acclimatized and Non-Acclimatized Humans. Endocrinology. 2020;161: pubmed publisher
Lucchini F, Wueest S, Challa T, Item F, Modica S, Borsigova M, et al. ASK1 inhibits browning of white adipose tissue in obesity. Nat Commun. 2020;11:1642 pubmed publisher
Tian Q, Zhao J, Yang Q, Wang B, Deavila J, Zhu M, et al. Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. Aging Cell. 2020;19:e13059 pubmed publisher
Quiroga D, Miquet J, Gonzalez L, Sotelo A, Muñoz M, Geraldes P, et al. Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity. Mol Cell Endocrinol. 2019;498:110587 pubmed publisher
Odermatt T, Dedual M, Borsigova M, Wueest S, Konrad D. Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction. Int J Obes (Lond). 2020;44:707-714 pubmed publisher
Fayyad A, Khan A, Abdallah S, Alomran S, Bajou K, Khattak M. Rosiglitazone Enhances Browning Adipocytes in Association with MAPK and PI3-K Pathways During the Differentiation of Telomerase-Transformed Mesenchymal Stromal Cells into Adipocytes. Int J Mol Sci. 2019;20: pubmed publisher
Xie X, Yang H, An J, Houtz J, Tan J, Xu H, et al. Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure. Cell Metab. 2019;29:917-931.e4 pubmed publisher
West M, Chang C, LAROCCA D, Li J, Jiang J, Sim P, et al. Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells. Stem Cell Res Ther. 2019;10:7 pubmed publisher
Balaz M, Becker A, Balazova L, Straub L, Müller J, Gashi G, et al. Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation. Cell Metab. 2019;29:901-916.e8 pubmed publisher
Rotter D, Peiris H, Grinsfelder D, Martin A, Burchfield J, Parra V, et al. Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis. EMBO Rep. 2018;19: pubmed publisher
Robbins A, Tom C, Cosman M, Moursi C, Shipp L, Spencer T, et al. Low temperature decreases bone mass in mice: Implications for humans. Am J Phys Anthropol. 2018;167:557-568 pubmed publisher
Fabbiano S, Suárez Zamorano N, Chevalier C, Lazarevic V, Kieser S, Rigo D, et al. Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements. Cell Metab. 2018;28:907-921.e7 pubmed publisher
Quiroga D, Muñoz M, Gil C, Pffeifer M, Toblli J, Steckelings U, et al. Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice. Physiol Rep. 2018;6:e13824 pubmed publisher
Krieger J, Santos da Conceição E, Sanchez Watts G, Arnold M, Pettersen K, Mohammed M, et al. Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats. Am J Physiol Regul Integr Comp Physiol. 2018;315:R708-R720 pubmed publisher
Clayton Z, McCurdy C. Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice. Am J Physiol Regul Integr Comp Physiol. 2018;315:R627-R637 pubmed publisher
Babaei R, Schuster M, Meln I, Lerch S, Ghandour R, Pisani D, et al. Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis. Sci Signal. 2018;11: pubmed publisher
Lee S, Sanchez Watts G, Krieger J, Pignalosa A, Norell P, Cortella A, et al. Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity. Mol Metab. 2018;11:33-46 pubmed publisher
Gorski T, Mathes S, Krutzfeldt J. Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control. J Cachexia Sarcopenia Muscle. 2018;9:384-399 pubmed publisher
Zhou Q, Song Y, Huang C, Huang J, Gong Z, Liao Z, et al. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018;38: pubmed publisher
Wang B, Zhang F, Zhang H, Wang Z, Ma Y, Zhu M, et al. Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia. Oncotarget. 2017;8:100411-100420 pubmed publisher
Suárez Zamorano N, Fabbiano S, Chevalier C, Stojanović O, Colin D, Stevanović A, et al. Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat Med. 2015;21:1497-1501 pubmed publisher
Neinast M, Frank A, Zechner J, Li Q, Vishvanath L, Palmer B, et al. Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning. Mol Metab. 2015;4:427-36 pubmed publisher
Than A, He H, Chua S, Xu D, Sun L, Leow M, et al. Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes. J Biol Chem. 2015;290:14679-91 pubmed publisher
product information
Product Type :
Antibody
Product Name :
UCP1 Polyclonal Antibody
Catalog # :
PA1-24894
Quantity :
100 µL
Price :
US 496.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Feline, Ferret, Human, Mouse, Rat
Applications :
Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000
Species :
Feline, Ferret, Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Mitochondrial uncoupling proteins are members of the family of mitochondrial anion carrier proteins. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
Immunogen :
Synthetic peptide, conjugated to KLH, corresponding to residues 145-159 of human UCP1, with an N-terminal added cysteine.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000
Aliases :
AI385626; HGNC:12517; mitochondrial brown fat uncoupling protein 1; SLC25A7; solute carrier family 25 member 7; Thermogenin; Ucp; UCP 1; Ucp1; Ucpa; uncoupling protein; uncoupling protein 1; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial; Uncp; unnamed protein product
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA