p35 Polyclonal Antibody | Invitrogen PA1-24756 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p35 Polyclonal Antibody

catalog :

PA1-24756

quantity :

100 µL

price :

375 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

p35 Polyclonal Antibody

Catalog # :

PA1-24756

Quantity :

100 µL

Price :

375 USD

Clonality :

Polyclonal

Purity :

IgG fraction

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Western Blot: 1:1000

Species :

Human, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Immunogen :

Synthetic peptide, conjugated to KLH, corresponding to residues 192-209 of human p35 Nck5a.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1000

Aliases :

CDK5 activator 1; CDK5P35; Cdk5r; Cdk5r1; cyclin dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); D11Bwg0379e; Nck5a; neuronal CDK5 activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit