VEGF Polyclonal Antibody | Invitrogen PA1-21796 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VEGF Polyclonal Antibody

catalog :

PA1-21796

quantity :

500 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; 1:50; fig 3	Liang X, Guo Y, Sun T, Song H, Gao Y. Anti-angiogenic effect of total saponins of Rhizoma Dioscorea nipponica on collagen induced-arthritis in rats. Exp Ther Med. 2016;12:2155-2160 pubmed
	Budiatin A, Khotib J, Samirah S, Ardianto C, Gani M, Putri B, et al. Acceleration of Bone Fracture Healing through the Use of Bovine Hydroxyapatite or Calcium Lactate Oral and Implant Bovine Hydroxyapatite-Gelatin on Bone Defect Animal Model. Polymers (Basel). 2022;14: pubmed publisher
	Górowska Wójtowicz E, Duliban M, Kotula Balak M, Bilinska B. Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells. Biomedicines. 2022;10: pubmed publisher
	Henn D, Chen K, Fehlmann T, Trotsyuk A, Sivaraj D, Maan Z, et al. Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages. Sci Adv. 2021;7:eabi4528 pubmed publisher
	Bakr M, Radwan E, Shaltout A, Farrag A, Mahmoud A, Abd Elhamid T, et al. Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice. Sci Rep. 2021;11:18772 pubmed publisher
	Budiatin A, Gani M, Samirah -, Ardianto C, Raharjanti A, Septiani I, et al. Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect. Int J Biomater. 2021;2021:5560891 pubmed publisher
	Hasan S, Sultana S. Geraniol attenuates 2-acetylaminofluorene induced oxidative stress, inflammation and apoptosis in the liver of wistar rats. Toxicol Mech Methods. 2015;25:559-73 pubmed publisher

product information

Product Type :

Antibody

Product Name :

VEGF Polyclonal Antibody

Catalog # :

PA1-21796

Quantity :

500 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 5-10 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

4 C, do not freeze

Description :

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.

Immunogen :

Human recombinant VEGF 165.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 5-10 ug/mL

Aliases :

angiogenic factor; etID309976.16; eVEGF120; eVEGF164; human VEGF121 homolog; MGC70609; MVCD1; ovine vascular endothelial growth factor; RP1-261G23.1; unnamed protein product; VAS; vascular endothelial growth factor; vascular endothelial growth factor (VEGF) precursor; vascular endothelial growth factor 121 isoform; vascular endothelial growth factor 164; vascular endothelial growth factor 165b; vascular endothelial growth factor 182; vascular endothelial growth factor 182 isoform; vascular endothelial growth factor 188; vascular endothelial growth factor 188 isoform; vascular endothelial growth factor 189; vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular endothelial growth factor Aa; Vascular endothelial growth factor A-A; vascular endothelial growth factor isoform 165; vascular permeability factor; Vasculotropin; VEGF; VEGF1; VEGF164; VEGF182; VEGF188; vegfa; VEGF-A; VEGFA165b; vegfaa; VEGF-A-A; VEGFMGC70609; VPF; VPF ant; wu:fj82c06

more info or order :

Invitrogen product webpage