This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
POLG Polyclonal Antibody
catalog :
PA1-21791
quantity :
500µL
price :
US 381.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunoprecipitation
citations: 1
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; human; fig 4
  • western blot; human; fig 4
Altilia S, Santoro A, Malagoli D, Lanzarini C, Ballesteros Álvarez J, Galazzo G, et al. TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells. Aging (Albany NY). 2012;4:28-39 pubmed
product information
Product Type :
Antibody
Product Name :
POLG Polyclonal Antibody
Catalog # :
PA1-21791
Quantity :
500µL
Price :
US 381.00
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
Western Blot: Assay dependent
Species :
Human
Isotype :
IgG
Storage :
4° C, do not freeze
Description :
As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.
Immunogen :
Purified native human recombinant amino acids 714 - 1061 DNA polymerase gamma.
Format :
Liquid
Applications w/Dilutions :
Western Blot: Assay dependent
Aliases :
FLJ27114, MDP1, PEO, POLG1, POLGA, SANDO, SCAE
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA