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antibody

CRYAB Polyclonal Antibody

PA1-20795

100 uL

US 522.00

polyclonal

domestic rabbit

nonconjugated

Chinese hamsters, human, mouse, rat, bovine, pigs , domestic rabbit

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

CRYAB Polyclonal Antibody

PA1-20795

100 uL

US 522.00

Polyclonal

protein A

Rabbit

Bovine, Hamster, Human, Mouse, Porcine, Rabbit, Rat

Immunocytochemistry: 1:200, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:2,000

Bovine, Hamster, Human, Mouse, Porcine, Rabbit, Rat

IgG

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.

Synthetic peptide:R(163)EEKPAVTAAPKK(175) KLH conjugated, corresponding to human alpha B Crystallin.

Liquid

Immunocytochemistry: 1:200, Immunohistochemistry: Assay-Dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:2,000

2310001E10Rik; 3526402H21Rik; AACRYA; active transcription factor CREB; alpha B-crystallin; alpha crystallin B; alpha(B)-crystallin; alpha-B-crystallin; Alpha-crystallin B chain; alpha-crystallin B chain-like protein; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CMD1II; CREB; CREB1; CREB-1; Crya2; Crya-2; CRYAB; CryAB antibody; crystallin alpha B; crystallin, alpha 2; crystallin, alpha B; crystallin, alpha polypeptide 2; CTPP2; CTRCT16; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; epididymis secretory protein Li 101; heat shock protein beta-5; heat shock protein CryAB; heat shock protein HspB5; heat-shock 20 kD like-protein; HEL-S-101; HSPB5; HspB5 protein; MFM2; P23; Renal carcinoma antigen NY-REN-27; rosenthal fiber component; transactivator protein; Y protein