PGP9.5 Polyclonal Antibody | Invitrogen PA1-20226 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PGP9.5 Polyclonal Antibody

catalog :

PA1-20226

quantity :

50µL

price :

US 345

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

guinea pig, human, mouse, rat, bovine, swine, domestic horse

application :

western blot

product information

Product Type :

Antibody

Product Name :

PGP9.5 Polyclonal Antibody

Catalog # :

PA1-20226

Quantity :

50µL

Price :

US 345

Clonality :

Polyclonal

Host :

Goat

Reactivity :

Bovine, Equine, Guinea Pig, Human, Mouse, Porcine, Rat

Applications :

Western Blot: Assay dependent

Species :

Bovine, Equine, Guinea Pig, Human, Mouse, Porcine, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. PGP9.5 has a molecular weight of 27 kDa and was first identified by high resolution two dimensional PAGE. PGP9.5 is a member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with a ubiquitin carboxyl-terminal hydrolase domain. PGP9.5 is well known for having ubiquitin hydrolase and ligase activities that hydrolyzes small C-terminal adducts of ubiquitin to generate ubiquitin monomers. PGP9.5 is present in neurons and nerve fibers at all levels of the central and peripheral nervous system, in neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. Over expression of PGP9.5 leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Since PGP9.5 is present in cellular inclusions, it can be a useful as a neuronal marker and in the studies of neurodegenerative disorders such as with Parkinson disease.

Immunogen :

Synthetic peptide corresponding to residues N(46) F R K K Q I E E L K G Q E V S P K(63) of human PGP9.5.

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay dependent

Aliases :

PARK5, PGP9.5, PGP95, Uch-L1