PSME4 Polyclonal Antibody | Invitrogen PA1-1961 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSME4 Polyclonal Antibody

catalog :

PA1-1961

quantity :

100 uL

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Reference
Ko xe7 berber Z, Willemsen N, Bartelt A. The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function. Front Endocrinol (Lausanne). 2023;14:1176733 pubmed publisher
Douida A, Batista F, Robaszkiewicz A, Boto P, Aladdin A, Szenykiv M, et al. The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells. J Cell Mol Med. 2020;24:6716-6730 pubmed publisher
Lokireddy S, Kukushkin N, Goldberg A. cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins. Proc Natl Acad Sci U S A. 2015;112:E7176-85 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PSME4 Polyclonal Antibody

Catalog # :

PA1-1961

Quantity :

100 uL

Price :

US 451.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:600, Immunoprecipitation: Assay-dependent, Western Blot: 1:250

Species :

Bovine, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [UniProt]

Immunogen :

Synthetic peptide corresponding to residues T(1620) K L P K K R K R D P G S V G(1634) of human PA200.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:600, Immunoprecipitation: Assay-dependent, Western Blot: 1:250

Aliases :

AA409398; AU041366; Kiaa0077; mKIAA0077; PA200; proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; proteasome activator complex subunit 4; Proteasome activator PA200; proteasome activator subunit 4; Protein TEMO; Psme4; TEMO