TrkB Polyclonal Antibody | Invitrogen PA1-18403 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TrkB Polyclonal Antibody

catalog :

PA1-18403

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

immunohistochemistry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

TrkB Polyclonal Antibody

Catalog # :

PA1-18403

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Mouse, Rat

Applications :

ELISA: 1:10,000, Immunohistochemistry (Frozen): 1:1,000-1:3,000

Species :

Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

Immunogen :

Extracellular domain of glycosylated mouse TrkB protein produced in CHO cells.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 1:10,000, Immunohistochemistry (Frozen): 1:1,000-1:3,000

Aliases :

AI848316; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 2; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; Ntrk2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; RATTRKB1; Tkrb; Trk B; TRKB; trk-B; trkB protein; trkB tyrosine kinase; TRKB1; Tropomyosin-related kinase B; tyrosine kinase receptor B