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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Versican V0, V1 Neo Polyclonal Antibody
catalog :
PA1-1748A
quantity :
100 ug
price :
US 451.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5f
Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Addinsall A, Forgan L, McRae N, Kelly R, McDonald P, McNeill B, et al. Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles. Biomolecules. 2020;10: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s13b
Diéguez Hurtado R, Kato K, Giaimo B, Nieminen Kelhä M, Arf H, Ferrante F, et al. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019;10:2817 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Dubail J, Vasudevan D, Wang L, Earp S, Jenkins M, Haltiwanger R, et al. Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep. 2016;6:33974 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1
Zhou Z, Tang A, Wong W, Bamezai S, Goddard L, Shenkar R, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016;532:122-6 pubmed publisher
Minns A, Santamaria S. Determination of Versikine Levels by Enzyme-Linked Immunosorbent Assay (ELISA). Methods Mol Biol. 2024;2747:83-93 pubmed publisher
Motter Catarino C, Cigaran Schuck D, Dechiario L, Karande P. Incorporation of hair follicles in 3D bioprinted models of human skin. Sci Adv. 2023;9:eadg0297 pubmed publisher
Papadas A, Deb G, Cicala A, Officer A, Hope C, Pagenkopf A, et al. Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment. Cell Rep. 2022;40:111201 pubmed publisher
Foulcer S, Day A, Apte S. Isolation and Purification of Versican and Analysis of Versican Proteolysis. Methods Mol Biol. 2022;2303:559-578 pubmed publisher
Santamaria S, Cuffaro D, Nuti E, Ciccone L, Tuccinardi T, Liva F, et al. Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide. Sci Rep. 2021;11:949 pubmed publisher
Nandadasa S, Szafron J, Pathak V, Murtada S, Kraft C, O Donnell A, et al. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. elife. 2020;9: pubmed publisher
Hong C, Tang A, Detter M, Choi J, Wang R, Yang X, et al. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020;217: pubmed publisher
McRae N, Addinsall A, Howlett K, McNeill B, McCulloch D, Stupka N. Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles. Sci Rep. 2020;10:11080 pubmed publisher
Binder M, McCoombe S, Williams E, McCulloch D, Ward A. ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer. Biomolecules. 2020;10: pubmed publisher
Sandireddy R, Cibi D, Gupta P, Singh A, Tee N, Uemura A, et al. Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. JCI Insight. 2019;4: pubmed publisher
Hemmeryckx B, Carai P, Roger Lijnen H. ADAMTS5 deficiency in mice does not affect cardiac function. Cell Biol Int. 2019;43:593-604 pubmed publisher
Dhakal B, Pagenkopf A, Mushtaq M, Cunningham A, Flietner E, Morrow Z, et al. Versican proteolysis predicts immune effector infiltration and post-transplant survival in myeloma. Leuk Lymphoma. 2019;60:2558-2562 pubmed publisher
Lin W, Li D, Cheng L, Li L, Liu F, Hand N, et al. Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018;128:826-833 pubmed publisher
McRae N, Forgan L, McNeill B, Addinsall A, McCulloch D, van der Poel C, et al. Glucocorticoids Improve Myogenic Differentiation In Vitro by Suppressing the Synthesis of Versican, a Transitional Matrix Protein Overexpressed in Dystrophic Skeletal Muscles. Int J Mol Sci. 2017;18: pubmed publisher
Hope C, Emmerich P, Papadas A, Pagenkopf A, Matkowskyj K, Van De Hey D, et al. Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. J Immunol. 2017;199:1933-1941 pubmed publisher
Gueye N, Mead T, Koch C, Biscotti C, Falcone T, Apte S. Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma. J Clin Endocrinol Metab. 2017;102:1631-1641 pubmed publisher
Carthy J, Abraham T, Meredith A, Boroomand S, McManus B. Versican localizes to the nucleus in proliferating mesenchymal cells. Cardiovasc Pathol. 2015;24:368-74 pubmed publisher
Snyder J, Washington I, Birkland T, Chang M, Frevert C. Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry. J Histochem Cytochem. 2015;63:952-67 pubmed publisher
Nandadasa S, Nelson C, Apte S. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015;11:1519-28 pubmed publisher
Tian E, Stevens S, Guan Y, Springer D, Anderson S, Starost M, et al. Galnt1 is required for normal heart valve development and cardiac function. PLoS ONE. 2015;10:e0115861 pubmed publisher
Zhuang Y, Nguyen H, Burow M, Zhuo Y, El Dahr S, Yao X, et al. Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells. Mol Carcinog. 2015;54:1656-67 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Versican V0, V1 Neo Polyclonal Antibody
Catalog # :
PA1-1748A
Quantity :
100 ug
Price :
US 451.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Western Blot: 1 ug/mL
Species :
Human
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Versican is a member of the family of large aggregating proteoglycans (also including aggrecan, brevican, and neurocan). The protein shows wide tissue distribution which includes fibrous, articular, and elastic cartilages, as well as nervous, epidermal, arterial, and loose connective tissues. Versican V1 has been shown to enhance cell proliferation, and also induce cell transformation and protect cells from apoptosis. This was demonstrated through its ability to downregulate the expression of proapoptotic Bad. Versican's existence as a extracellular matrix protein in human airways has also lead to the discovery of an inflammatory role in asthmatics.
Immunogen :
Synthetic peptide corresponding to residues C G G D(436) P E A A E(441) of human Versican V0/V1 Neo.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1 ug/mL
Aliases :
Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; CSPG2; ERVR; GHAP; Glial hyaluronate-binding protein; large fibroblast proteoglycan; PGM; PG-M; V1 Neo; VCAN; versican; versican core protein; versican proteoglycan; Versican V0; WGN; WGN 1; WGN1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA