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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Aggrecan Neo Polyclonal Antibody
catalog :
PA1-1746
quantity :
100 ug
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, bovine, pigs
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 6a
Coveney C, Zhu L, Miotla Zarebska J, Stott B, Parisi I, Batchelor V, et al. Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in Mice. Arthritis Rheumatol. 2022;74:49-59 pubmed publisher
  • western blot; human; 1 ug/ml; loading ...; fig s3b
Yin 殷晓科 X, Wanga S, Fellows A, Barallobre Barreiro J, Lu R, Davaapil H, et al. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients. Arterioscler Thromb Vasc Biol. 2019;39:1859-1873 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3
Mével E, Merceron C, Vinatier C, Krisa S, Richard T, Masson M, et al. Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1? activities before and after oral consumption. Sci Rep. 2016;6:33527 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 2
Ismail H, Miotla Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, et al. Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis. Arthritis Rheumatol. 2016;68:1165-71 pubmed publisher
Zheng X, Qiu J, Gao N, Jiang T, Li Z, Zhang W, et al. Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression. Drug Des Devel Ther. 2023;17:2383-2399 pubmed publisher
Shi W, Wu J, Pi Y, Yan X, Hu X, Cheng J, et al. E7 Peptide Enables BMSC Adhesion and Promotes Chondrogenic Differentiation of BMSCs Via the LncRNA H19/miR675 Axis. Bioengineering (Basel). 2023;10: pubmed publisher
Mern D, Thom xe9 C. Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2. Exp Biol Med (Maywood). 2023;248:1134-1144 pubmed publisher
Gong Y, Qiu J, Jiang T, Li Z, Zhang W, Zheng X, et al. Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis. Inflammopharmacology. 2023;31:369-384 pubmed publisher
Zheng X, Qiu J, Pan W, Gong Y, Zhang W, Jiang T, et al. Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment. Front Pharmacol. 2022;13:938133 pubmed publisher
Zhang W, Gong Y, Zheng X, Qiu J, Jiang T, Chen L, et al. Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway. Front Pharmacol. 2021;12:799130 pubmed publisher
Xu R, Zhang F, Lu J, Wang K, Pan P, Sun Y, et al. Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip. Aging (Albany NY). 2021;13:11281-11295 pubmed publisher
Nandadasa S, Szafron J, Pathak V, Murtada S, Kraft C, O Donnell A, et al. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. elife. 2020;9: pubmed publisher
Schneider M, Chu S, Randolph M, Bryant S. An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly(ethylene glycol) hydrogels with localized transforming growth factor β3. Acta Biomater. 2019;: pubmed publisher
Guns L, Monteagudo S, Kvasnytsia M, Kerckhofs G, Vandooren J, Opdenakker G, et al. Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo. RMD Open. 2017;3:e000604 pubmed publisher
Suna G, Wojakowski W, Lynch M, Barallobre Barreiro J, Yin X, Mayr U, et al. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018;137:166-183 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Aggrecan Neo Polyclonal Antibody
Catalog # :
PA1-1746
Quantity :
100 ug
Price :
US 471.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Bovine, Canine, Human, Mouse, Porcine, Rat
Applications :
Immunohistochemistry: Assay-dependent, Western Blot: 1 ug/mL
Species :
Bovine, Canine, Human, Mouse, Porcine, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be used to detect these neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
Immunogen :
Synthetic peptide corresponding to residues C G G N(387) I T E G E(392) of human aggrecan.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: Assay-dependent, Western Blot: 1 ug/mL
Aliases :
Acan; Agc; AGC1; AGCAN; aggrecan; aggrecan 1; aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122); aggrecan core protein; Aggrecan core protein 2; aggrecan CS2 domain; aggrecan epidermal growth factor-like domain-1; aggrecan G2 domain; aggrecan interglobular domain; aggrecan keratan sulfate domain; aggrecan, structural proteoglycan of cartilage; articular cartilage aggrecan precursor; b2b183Clo; cartilage aggregating proteoglycan; cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; chondroitin sulfate proteoglycan core protein 1; cmd; CSPCP; CSPG1; CSPGCP; high density cartilage proteoglycan; large aggregating proteoglycan; large aggregating proteoglycan, antigen; MSK16; SEDK
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA