LOX Polyclonal Antibody | Invitrogen PA1-16953 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LOX Polyclonal Antibody

catalog :

PA1-16953

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
Steppan J, Nandakumar K, Wang H, Jang R, Smith L, Kang S, et al. Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases. Physiol Rep. 2023;11:e15656 pubmed publisher
Gautam S, Rawat A, Sammi S, Roy S, Singh M, Devi U, et al. DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention. Front Pharmacol. 2018;9:314 pubmed publisher
Moorer M, Hebert C, Tomlinson R, Iyer S, Chason M, Stains J. Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation. J Cell Sci. 2017;130:531-540 pubmed publisher
Chen Z, Li Y, Xu H, Ma F, Li J, Zhao L, et al. Elevated ischaemia-associated lysyl oxidase activity in delayed graft failure 6-12 months after renal transplantation. Exp Physiol. 2017;102:282-287 pubmed publisher
Somanna N, Valente A, Krenz M, Fay W, Delafontaine P, Chandrasekar B. The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4. J Cell Physiol. 2016;231:1130-41 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LOX Polyclonal Antibody

Catalog # :

PA1-16953

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Porcine, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:100-1:250, Western Blot: 0.5-4 ug/mL

Species :

Human, Mouse, Porcine, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

Immunogen :

Synthetic peptide between amino acids 200-300 of the human LOX protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:100-1:250, Western Blot: 0.5-4 ug/mL

Aliases :

AI893619; cross-linking enzyme; H-rev142; LOX; Lysyl oxidase; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); MGC105112; protein-lysine 6-oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form; Ras excision protein; ras recision; rrg; Rrg1; TSC-160