LC3B Polyclonal Antibody | Invitrogen PA1-16930 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LC3B Polyclonal Antibody

catalog :

PA1-16930

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

guinea pig, Chinese hamsters, human, mouse, rat, dogs, chicken, bovine, pigs , zebrafish , domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay

more info or order :

Invitrogen product webpage

citations: 26

Published Application/Species/Sample/Dilution	Reference
western blot; bovine; 1:500; fig 1	Wohlgemuth S, Ramirez Lee Y, Tao S, Monteiro A, Ahmed B, Dahl G. Short communication: Effect of heat stress on markers of autophagy in the mammary gland during the dry period. J Dairy Sci. 2016;99:4875-4880 pubmed publisher
western blot; mouse; 1:1000; fig 3	Scotton C, Bovolenta M, Schwartz E, Falzarano M, Martoni E, Passarelli C, et al. Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy. J Cell Sci. 2016;129:1671-84 pubmed publisher
	Cristovao B, Rodrigues L, Catarino S, Abreu M, Gon xe7 alves T, Domingues N, et al. Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection. Microbiol Spectr. 2023;11:e0123823 pubmed publisher
	Macedo da Silva J, Rosa Fernandes L, Gomes V, Santiago V, Santos D, Molnar C, et al. Protein Arginylation Is Regulated during SARS-CoV-2 Infection. Viruses. 2023;15: pubmed publisher
	Barazzuol L, Cieri D, Facchinello N, Cal xec T, Washbourne P, Argenton F, et al. Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Cells. 2023;12: pubmed publisher
	Dhanabalan K, Dravid A, Agarwal S, Sharath R, Padmanabhan A, Agarwal R. Intra-articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis. Bioeng Transl Med. 2023;8:e10298 pubmed publisher
	Ibrahim W, Kamel A, Wahid A, Abdelkader N. Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/D-galactose Alzheimer's rat model. Inflammopharmacology. 2022;30:2505-2520 pubmed publisher
	Remy J, Linder B, Weirauch U, Day B, Stringer B, Herold Mende C, et al. STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers (Basel). 2022;14: pubmed publisher
	L xf6 wen J, Gr xf6 ne E, Gro xdf Wei xdf mann M, Bestvater F, Gr xf6 ne H, Kriz W. Pathomorphological sequence of nephron loss in diabetic nephropathy. Am J Physiol Renal Physiol. 2021;321:F600-F616 pubmed publisher
	Fu Y, Chen N, Wang Z, Luo S, Ding Y, Lu B. Degradation of lipid droplets by chimeric autophagy-tethering compounds. Cell Res. 2021;: pubmed publisher
	Tomic S, Đokić J, Stevanovic D, Ilic N, Gruden Movsesijan A, Dinić M, et al. Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients. Front Immunol. 2021;12:614599 pubmed publisher
	Metti S, Gambarotto L, Chrisam M, Baraldo M, Braghetta P, Blaauw B, et al. The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction. Front Cell Dev Biol. 2020;8:580933 pubmed publisher
	Zielke S, Kardo S, Zein L, Mari M, Covarrubias Pinto A, Kinzler M, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2020;:1-17 pubmed publisher
	Catarino S, Ribeiro Rodrigues T, Sá Ferreira R, Ramalho J, Abert C, Martens S, et al. A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins. Cells. 2020;9: pubmed publisher
	Toms M, Dubis A, de Vrieze E, Tracey White D, Mitsios A, Hayes M, et al. Clinical and preclinical therapeutic outcome metrics for USH2A-related disease. Hum Mol Genet. 2020;29:1882-1899 pubmed publisher
	Ma J, Ramachandran M, Jin C, Quijano Rubio C, Martikainen M, Yu D, et al. Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer. Cell Death Dis. 2020;11:48 pubmed publisher
	Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019;: pubmed publisher
	Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, et al. Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. Cell Rep. 2019;28:104-118.e8 pubmed publisher
	Meneghetti G, Skobo T, Chrisam M, Facchinello N, Fontana C, Bellesso S, et al. The epg5 knockout zebrafish line: a model to study Vici syndrome. Autophagy. 2019;15:1438-1454 pubmed publisher
	Lian W, Ko J, Chen Y, Ke H, Wu S, Kuo C, et al. Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR. Cell Death Dis. 2018;9:938 pubmed publisher
	Kim S, Kim D, Park K, Kim M, Park Y, Muallem S, et al. Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy. Autophagy. 2019;15:327-340 pubmed publisher
	Meyer N, Zielke S, Michaelis J, Linder B, Warnsmann V, Rakel S, et al. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14:1693-1709 pubmed publisher
	Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, de Tullio P, et al. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature. 2018;558:605-609 pubmed publisher
	Wang H, Wang H, Liang E, Zhou L, Dong Z, Liang P, et al. Thrombopoietin protects H9C2 cells from excessive autophagy and apoptosis in doxorubicin-induced cardiotoxicity. Oncol Lett. 2018;15:839-848 pubmed publisher
	Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, et al. Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy. 2015;11:2142-52 pubmed publisher
	Huna A, Salmina K, Erenpreisa J, Vazquez Martin A, Krigerts J, Inashkina I, et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle. 2015;14:2969-84 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LC3B Polyclonal Antibody

Catalog # :

PA1-16930

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Avian, Bacteria, Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Invertebrate, Mouse, Non-human primate, Porcine, Rabbit, Rat, Zebrafish

Applications :

ChIP Assay: Assay-Dependent, ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 20 ug/500 ug of protein, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 0.5-2 ug/mL

Species :

Avian, Bacteria, Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Invertebrate, Mouse, Non-human primate, Porcine, Rabbit, Rat, Zebrafish

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.

Immunogen :

Synthetic peptide between amino acids 1-100 of the human LC3 protein.

Format :

Liquid

Applications w/Dilutions :

Aliases :

1010001C15Rik; Atg8; ATG8E; ATG8F; ATG8G; Autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3; LC3 beta; LC3A; LC3B; light chain 3; MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Map1alc3; MAP1BLC3; MAP1LC3; MAP1LC3A; MAP1LC3B; MAP1LC3B2; MAP1LC3B-a; microtubule associated protein 1 light chain 3 beta; microtubule associated protein 1 light chain 3 beta 2; microtubule-associated protein 1 light chain 3; microtubule-associated protein 1 light chain 3 beta; microtubule-associated protein 1 light chain 3 beta 2; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3 beta 2; Microtubule-associated proteins 1A/1B light chain 3B; Microtubule-associated proteins 1A/1B light chain 3B-like; Microtubule-associated proteins 1A/1B light chain 3B-like protein; Mpl3; RP11-346K17.1; wu:fb60g11; zbs559; zgc:56434

more info or order :

Invitrogen product webpage