This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
catalog :
PA1-16927
quantity :
100 uL
price :
US 470.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
domestic goat, human, mouse, rat, pigs , domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 48
Reference
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Shen W, Wang B, Yao R, Goetzinger K, Wu S, Gao H, et al. Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling. Front Cell Dev Biol. 2023;11:1023327 pubmed publisher
Brownrigg G, Xia Y, Chu C, Wang S, Chao C, Zhang J, et al. Sex differences in islet stress responses support female β cell resilience. Mol Metab. 2023;69:101678 pubmed publisher
Chen W, Liu P, Liu D, Huang H, Feng X, Fang F, et al. Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. Nat Commun. 2022;13:6796 pubmed publisher
Gao X, Lin S, Jiang P, Ye M, Chen W, Hu C, et al. Gestational cholestasis induced intrauterine growth restriction through triggering IRE1α-mediated apoptosis of placental trophoblast cells. FASEB J. 2022;36:e22388 pubmed publisher
Peterson Reynolds C, Mantis N. Differential ER stress as a driver of cell fate following ricin toxin exposure. FASEB Bioadv. 2022;4:60-75 pubmed publisher
Durán I, Zieba J, Csukasi F, Martin J, Wachtell D, Barad M, et al. 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2022;37:675-686 pubmed publisher
Su W, YU X, Zhou C. SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response. Viruses. 2021;13: pubmed publisher
Guo Y, Hao D, Hu H. High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts. Mol Biol Rep. 2021;48:7841-7851 pubmed publisher
Chaudhary P, Sharma S, Singh R, Arya R. Elucidation of ER stress and UPR pathway in sialic acid-deficient cells: Pathological relevance to GNEM. J Cell Biochem. 2021;122:1886-1902 pubmed publisher
Zhou Y, Wan X, Seidel K, Zhang M, Goodman J, Seta F, et al. Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE-/- Mice. J Am Heart Assoc. 2021;10:e020441 pubmed publisher
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
Akhter M, Uddin M, Kubra K, Barabutis N. Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs. Pharmaceuticals (Basel). 2021;14: pubmed publisher
Li W, Wang Y, Zhu L, DU S, Mao J, Wang Y, et al. The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. J Cell Mol Med. 2021;25:6709-6720 pubmed publisher
Barabutis N, Akhter M, Kubra K, Uddin M. Restoring the endothelial barrier function in the elderly. Mech Ageing Dev. 2021;196:111479 pubmed publisher
Yi S, Shi W, Zuo M, Wang S, Ma R, Bi H, et al. Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells. Anal Cell Pathol (Amst). 2021;2021:5565671 pubmed publisher
Tan L, Harper L, Armstrong A, Carlson C, Yammani R. Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints. PLoS ONE. 2021;16:e0247237 pubmed publisher
Thomson S, Waters K, Machaalani R. The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS). Mol Neurobiol. 2021;58:2242-2255 pubmed publisher
Akhter M, Uddin M, Schally A, Kubra K, Barabutis N. Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs. J Cell Commun Signal. 2021;15:125-129 pubmed publisher
Chen Y, Griffiths A, Wang J, Zhang T, Song Q, Song Z. Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes. Am J Physiol Cell Physiol. 2020;319:C1130-C1140 pubmed publisher
Moghadami A, Aboutalebi Vand Beilankouhi E, Kalantary Charvadeh A, Hamzavi M, Mosayyebi B, Sedghi H, et al. Inhibition of USP14 induces ER stress-mediated autophagy without apoptosis in lung cancer cell line A549. Cell Stress Chaperones. 2020;25:909-917 pubmed publisher
Buchanan H, Mackay M, Palmer K, Tothová K, Katsur M, Platt B, et al. Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer's Disease. Mol Neurobiol. 2020;57:3258-3272 pubmed publisher
Huang H, Tian X, Peng X, Huang L, Mei L, Zhan Y, et al. Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action. Adv Clin Exp Med. 2020;29:535-545 pubmed publisher
Zhang Z, Cui D, Zhang T, Sun Y, Ding S. Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM. Diabetes Metab Syndr Obes. 2020;13:1417-1428 pubmed publisher
Jung E, Yoo Y, Park S, Ahn C, Jeon B, Hong E, et al. Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease. Cell Physiol Biochem. 2020;54:438-456 pubmed publisher
Kolpikova E, Tronco A, Hartigh A, Jackson K, Iwawaki T, Fink S. IRE1α Promotes Zika Virus Infection via XBP1. Viruses. 2020;12: pubmed publisher
Tan L, Harper L, McNulty M, Carlson C, Yammani R. High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints. FASEB J. 2020;34:5818-5826 pubmed publisher
Wang C, Liang S, Xing S, Xu K, Xiao H, Deng H, et al. Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type. Front Genet. 2020;11:36 pubmed publisher
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Mytych J, Sołek P, Będzińska A, Rusinek K, Warzybok A, Tabęcka Łonczyńska A, et al. Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. Cells. 2020;9: pubmed publisher
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb R, et al. Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nat Immunol. 2020;21:158-167 pubmed publisher
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Trotta M, Maisto R, Guida F, Boccella S, Luongo L, Baltă C, et al. The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome. PLoS ONE. 2019;14:e0211005 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
Catalog # :
PA1-16927
Quantity :
100 uL
Price :
US 470.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Drosophila, Goat, Human, Mammalia, Mouse, Non-human primate, Porcine, Rabbit, Rat
Applications :
ChIP Assay: Assay-dependent, ELISA: 1:100-1:2,000, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:10-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Immunoprecipitation: 1:10-1:500, In vitro Assay: Assay-Dependent, Western Blot: 1:500-1:1,000
Species :
Drosophila, Goat, Human, Mammalia, Mouse, Non-human primate, Porcine, Rabbit, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
ERN1 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells. ERN1 has a critical function in extraembryonic cells that is essential for fetal viability. Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.
Immunogen :
Synthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein.[Swiss-Prot #O75460]
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: Assay-dependent, ELISA: 1:100-1:2,000, Immunocytochemistry: 1:10-1:500, Immunohistochemistry (Frozen): 1:10-1:500, Immunohistochemistry (Paraffin): 1:10-1:500, Immunoprecipitation: 1:10-1:500, In vitro Assay: Assay-Dependent, Western Blot: 1:500-1:1,000
Aliases :
9030414B18Rik; AI225830; C85377; endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signalling 1; endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signalling 1; ERN1; FLJ30999; hIRE1p; inositol-requiring 1; inositol-requiring 1 alpha; inositol-requiring enzyme 1; inositol-requiring protein 1; IRE1; IRE1a; IRE1a antibody; Ire1alpha; Ire1-alpha; Ire1p; IRE1p antibody; MGC163277; MGC163279; protein kinase/endoribonuclease; RGD1559716; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE1-like
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA