Survivin Polyclonal Antibody | Invitrogen PA1-16836 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Survivin Polyclonal Antibody

catalog :

PA1-16836

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

guinea pig, human, mouse, rat, dogs, cat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; loading ...; fig 5a	Lin T, Chan H, Chen S, Sarvagalla S, Chen P, Coumar M, et al. BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Autophagy. 2019;:1-18 pubmed publisher
	Liu P, Wang J, Peng S, Zhang D, Zhuang L, Liu C, et al. Suppression of phosphodiesterase IV enzyme by roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anaesthesia via PKA-CREB and MEK/ERK pathways. Eur J Neurosci. 2022;56:4317-4332 pubmed publisher
	Lei J, Deng Y, Ma S. Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice. Brain Behav. 2022;12:e2610 pubmed publisher
	Venturini G, Kokona D, Steiner B, Bulla E, Jovanovic J, Zinkernagel M, et al. In vivo analysis of onset and progression of retinal degeneration in the Nr2e3rd7/rd7 mouse model of enhanced S-cone sensitivity syndrome. Sci Rep. 2021;11:19032 pubmed publisher
	Ullah M, Liu D, Rai S, Razavi M, Concepcion W, Thakor A. Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury. Stem Cell Res Ther. 2020;11:398 pubmed publisher
	Ma H, Soderquist C, Marchi E, Scotto L, Bhagat G, O Connor O. Cancer testis antigen expression across T-cell lymphoma subtypes. Hematol Oncol. 2020;38:827-830 pubmed publisher
	Li G, Zhang H, Zhao L, Zhang Y, Yan D, Liu Y, et al. The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease. Pulm Circ. 2019;9:2045894019859480 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Survivin Polyclonal Antibody

Catalog # :

PA1-16836

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Feline, Guinea Pig, Hamster, Human, Mouse, Rat

Applications :

ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunocytochemistry: 1:50-1:250, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1,000

Species :

Canine, Feline, Guinea Pig, Hamster, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

Immunogen :

Recombinant human survivin, full-length.

Format :

Liquid

Applications w/Dilutions :

Aliases :

AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP

more info or order :

Invitrogen product webpage