DERL1 Polyclonal Antibody | Invitrogen PA1-16598 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DERL1 Polyclonal Antibody

catalog :

PA1-16598

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:5000; loading ...; fig 9	Kim J, La Gamma E, Estabrook T, Kudrick N, Nankova B. Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia. PLoS ONE. 2017;12:e0172789 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DERL1 Polyclonal Antibody

Catalog # :

PA1-16598

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Canine, Hamster, Human, Mouse

Applications :

Immunocytochemistry: 1:2,000, Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 1:1,000-1:5,000

Species :

Canine, Hamster, Human, Mouse

Isotype :

IgG

Storage :

4 C, do not freeze

Description :

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Immunogen :

Synthetic peptide corresponding to the C-terminal residues 200-251 of human Derlin-1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:2,000, Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 1:1,000-1:5,000

Aliases :

1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; DER1; DER-1; Der1-like domain family, member 1; der1-like protein 1; Derl1; derlin 1; derlin-1; DERtrin-1; RGD1311835; UNQ243/PRO276

more info or order :

Invitrogen product webpage