Carbonic Anhydrase IX Polyclonal Antibody | Invitrogen PA1-16592 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Carbonic Anhydrase IX Polyclonal Antibody

catalog :

PA1-16592

quantity :

100 µL

price :

US 496.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:2000; loading ...; fig 2a	Hoefflin R, Harlander S, Abhari B, Peighambari A, Adlesic M, Seidel P, et al. Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2021;13: pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig s4a	Carter P, Schnell U, Chaney C, TONG B, Pan X, ye J, et al. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021;131: pubmed publisher
	Abu El Maaty M, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, et al. Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv. 2022;8:eabo2295 pubmed publisher
	Refet Mollof E, Najyb O, Chermat R, Glory A, Lafontaine J, Wong P, et al. Hypoxic Jumbo Spheroids On-A-Chip (HOnAChip): Insights into Treatment Efficacy. Cancers (Basel). 2021;13: pubmed publisher
	Hoefflin R, Harlander S, Schäfer S, Metzger P, Kuo F, Schönenberger D, et al. HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun. 2020;11:4111 pubmed publisher
	Yao M, Sattler T, Rabbani Z, Pulliam T, Walker G, Gamcsik M. Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate. Am J Physiol Cell Physiol. 2018;315:C766-C775 pubmed publisher
	Wang H, Shepard M, Zhang C, Dong L, Walker D, Guedez L, et al. Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina. Cancer Res. 2018;78:1266-1274 pubmed publisher
	Gu Y, Cohn S, Christie A, McKenzie T, Wolff N, Do Q, et al. Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade. Cancer Discov. 2017;7:900-917 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Carbonic Anhydrase IX Polyclonal Antibody

Catalog # :

PA1-16592

Quantity :

100 µL

Price :

US 496.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Plant, Rat

Applications :

ChIP Assay: 1:10-1:500, ELISA: Assay-Dependent, Flow Cytometry: 1:1,000, Gel Shift: Assay-Dependent, Immunocytochemistry: 2-5 µg/mL, Immunohistochemistry (Frozen): 1:200-1:500, Immunohistochemistry (Paraffin): 1:200-1:500, Proximity Ligation Assay (PLA): Assay-Dependent, Western Blot: 1-3 µg/mL

Species :

Human, Mouse, Plant, Rat

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Immunogen :

A synthetic peptide derived from a C-terminal sequence of the human CA IX.

Format :

Liquid

Applications w/Dilutions :

Aliases :

Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250

more info or order :

Invitrogen product webpage